Home
  >  
Section 11
  >  
Chapter 10,481

Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells

Levy, O.; Orange, J.S.; Hibberd, P.; Steinberg, S.; LaRussa, P.; Weinberg, A.; Wilson, S.B.; Shaulov, A.; Fleisher, G.; Geha, R.S.; Bonilla, F.A.; Exley, M.

Journal of Infectious Diseases 188(7): 948-953

2003

ISSN/ISBN: 0022-1899
PMID: 14513412
DOI: 10.1086/378503
Accession: 010480159
Download citation:  
Text
  |  
BibTeX
  |  
RIS
An 11-year-old girl presented with a papulovesicular rash and severe respiratory distress 5 weeks after receiving varicella vaccine. Restriction fragment length-polymorphism analysis of virus isolated from an endotracheal-tube aspirate and from bronchoalveolar lavage revealed that this patient's illness was due to the Oka vaccine strain of varicella. An extensive immunologic analysis failed to identify a known diagnostic entity to explain her susceptibility to this attenuated vaccine strain. Analysis of her lymphocytes on separate occasions, months after recovery from her illness, revealed a profound deficiency of natural killer T (NKT) cells and of NKT-cell activity, suggesting that NKT cells contribute to host defense against varicella virus.

PDF emailed within 0-6 h: $19.90




Related References

Banovic, T.; Yanilla, M.; Simmons, R.; Robertson, I.; Schroder, W.A.; Raffelt, N.C.; Wilson, Y.A.; Hill, G.R.; Hogan, P.; Nourse, C.B. 2011: Disseminated varicella infection caused by varicella vaccine strain in a child with low invariant natural killer T cells and diminished CD1d expression Journal of Infectious Diseases 204(12): 1893-1901
Ghaffar, F.; Carrick, K.; Rogers, B.B.; Margraf, L.R.; Krisher, K.; Ramilo, O. 2000: Disseminated infection with varicella-zoster virus vaccine strain presenting as hepatitis in a child with adenosine deaminase deficiency Pediatric Infectious Disease Journal 19(8): 764-766
Arvin, A.M.; Moffat, J.F.; Redman, R. 1996: Varicella-zoster virus: aspects of pathogenesis and host response to natural infection and varicella vaccine Advances in Virus Research 46: 263-309
Diaz, P.S.; Smith, S.; Hunter, E.; Arvin, A.M. 1989: T lymphocyte cytotoxicity with natural varicella-zoster virus infection and after immunization with live attenuated varicella vaccine The Journal of Immunology (1950) 142(2): 636-641
Diaz, P.S.; Smith, S.; Hunter, E.; Arvin, A.M. 1989: T lymphocyte cytotoxicity with natural varicella-zoster virus infection and after immunization with live attenuated varicella vaccine Journal of Immunology 142(2): 636-641
Bhalla, P.; Forrest, G.N.; Gershon, M.; Zhou, Y.; Chen, J.; LaRussa, P.; Steinberg, S.; Gershon, A.A. 2015: Disseminated, persistent, and fatal infection due to the vaccine strain of varicella-zoster virus in an adult following stem cell transplantation Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 60(7): 1068-1074
Sohal, R.J.; Sohal, S.; George, T.; Gilotra, T. 2020: Varicella-Zoster Meningitis with Hypoglycorrhachia in an Immunocompetent Patient Presenting with Disseminated Varicella-Zoster Infection Cureus 12(6): E8539
Matsumoto, J.; Nakajima, A.; Suwa, A.; Yasuki, Y.; Yasui, T.; Inada, S. 2003: Successfully treated case with microscopic polyangiitis complicated severe varicella zoster virus infection including encephalitis and disseminated varicella zoster Ryumachi 43(4): 703-709
Malavige, G.N.; Jones, L.; Kamaladasa, S.D.; Wijewickrama, A.; Seneviratne, S.L.; Black, A.P.; Ogg, G.S. 2010: Natural killer cells during primary varicella zoster virus infection Journal of Infection 61(2): 190-192
Malavige, G.N.; Jones, L.; Kamaladasa, S.D.; Wijewickrama, A.; Seneviratne, S.L.; Black, A.P.; Ogg, G.S. 2010: Natural Killer Cells During Primary Varicella Zoster Virus Infection Journal of Infection 2010
Baba, K.; Yabuuchi, H.; Takahashi, M.; Bogger, S.; Ogra, P.L. 1982: Protective efficacy of live attenuated varicella zoster virus vaccine against naturally acquired varicella zoster infection Pediatric Research 16(4 Part 2): 148A
Sanchez Carazo, J.L.; Oliver Martinez, V.; Febrer Bosch, M.I.; Arnedo Grifol, A.L.; Martinez Escribano, J.A. 1994: Infección crónica diseminada por virus varicella-zoster en paciente con SIDA - Widespread chronic infection of virus varicella-zoster in an AIDS patient Actas Dermo-Sifiliograficas (Ed. Impresa) 85(7-8): 514-517
Leung, J.; Siegel, S.; Jones, J.F.; Schulte, C.; Blog, D.; Schmid, D.S.; Bialek, S.R.; Marin, M. 2014: Fatal varicella due to the vaccine-strain varicella-zoster virus Human Vaccines and Immunotherapeutics 10(1): 146-149
Novakova, L.; Lehuen, A.; Novak, J. 2011: Low numbers and altered phenotype of invariant natural killer T cells in recurrent varicella zoster virus infection Cellular Immunology 269(2): 78-81
Plisek, S.; Pliskova, L.; Bostik, V.; Prasil, P.; Laco, J.; Chlibek, R.; Vyroubal, P.; Kosina, P.; Bostik, P. 2011: Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology 50(1): 72-75
Shiraki, K.; Horiuchi, K.; Asano, Y.; Yamanishi, K.; Takahashi, M. 1991: Differentiation of oka varicella vaccine strain from wild varicella-zoster virus strains isolated from vaccinees and household contact Journal of Medical Virology 33(2): 128-132
Zeng, W.-B.; Zhang, F.; Cheng, S.; Sun, J.-Y.; Shen, H.; Luo, M.-H. 2021: Concerns on Vaccine against Varicella Caused by Varicella-Zoster Virus Infection Virologica Sinica 36(1): 159-162
Davidson, N.; Broom, J. 2019: Vaccine strain varicella zoster virus transmitted within a family from a child with shingles results in varicella meningitis in an immunocompetent adult Internal Medicine Journal 49(1): 132-133
Lässker, U.; Harder, T.C.; Hufnagel, M.; Suttorp, M. 2002: Rapid molecular discrimination between infection with wild-type varicella-zoster virus and varicella vaccine virus Infection 30(5): 320-322
Dubey, V.; MacFadden, D. 2019: Disseminated varicella zoster virus infection after vaccination with a live attenuated vaccine Cmaj: Canadian Medical Association Journal 191(37): E1025-E1027