+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Does eptifibatide confer a greater benefit to patients with unstable angina than with non-ST segment elevation myocardial infarction? Insights from the PURSUIT Trial

Does eptifibatide confer a greater benefit to patients with unstable angina than with non-ST segment elevation myocardial infarction? Insights from the PURSUIT Trial

European Heart Journal 23(14): 1102-1111

To evaluate the differential effects of eptifibatide therapy on unstable angina vs non-ST elevation myocardial infarction at enrollment, since the separate impact on these two major diagnostic subsets of acute coronary syndrome patients has not been fully investigated. We examined the 9461 patients in the PURSUIT trial (conducted between 1995 and 1997) to compare the effects of eptifibatide on unstable angina and myocardial infarction. The study showed greater and more consistent effects of eptifibatide therapy on unstable angina than non-ST elevation myocardial infarction in reducing 30-day death/(re)infarction (from the unadjusted rate of 13.0% to 11.2%, P=0.059 for unstable angina; and 18.9% to 17.9%, P=0.387 for myocardial infarction), especially among patients who underwent early percutaneous coronary intervention (odds ratios=0.49 and 0.86, 95% confidence intervals=0.30-0.80 and 0.53-1.42, respectively, for unstable angina and myocardial infarction). The only subgroup for whom the benefit of eptifibatide was not evident was female myocardial infarction patients who did not undergo early percutaneous coronary intervention. These data suggest that eptifibatide benefited unstable angina patients more than myocardial infarction patients, especially among those who underwent early percutaneous coronary intervention, and support its use as concomitant therapy with early percutaneous coronary intervention especially in female myocardial infarction patients.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 010490957

Download citation: RISBibTeXText

PMID: 12090748

DOI: 10.1053/euhj.2001.3151

Related references

Recurrent irritant contact dermatitis due to tributyltin oxide on work clothes. Contact Dermatitis 25(4): 250-251, 1991

Impact of diabetes mellitus on long-term survival after acute myocardial infarction is most obvious in patients with single-vessel disease. Circulation 100(18 Suppl. ): I 852, 1999

Health-related quality of life after intensity modulated radiation therapy for localized prostate cancer: comparison with conventional and conformal radiotherapy. Japanese Journal of Clinical Oncology 36(4): 224-230, 2006

Comparison of outcomes of patients with ST-segment elevation myocardial infarction with versus without previous coronary artery bypass grafting (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction [HORIZONS-AMI] trial). American Journal of Cardiology 111(10): 1377-1386, 2013

Do men and women differ in their response to interdisciplinary chronic pain management?. Pain 114(1-2): 37-46, 2005

Do localization economies matter in cluster formation? Questioning the conventional wisdom with data from Indian metropolises. Environment and Planning A 37(2): 331-353, 2005

Bleeding events in refractory cardiac arrest treated with extracorporeal membrane oxygenation--a single centre experience. Resuscitation 84(9): E119, 2013

Strategies and Therapies for Reducing Ischemic and Vascular Events (STRIVE) acute coronary syndromes Critical Pathway Toolkit. Critical Pathways in Cardiology 2(3): 153-177, 2003

Oral antiplatelet therapy in the secondary prevention of atherothrombotic events. American Journal of Cardiovascular Drugs 9(3): 197-209, 2009

Interventional vascular therapy: past experiences and future directions. Introduction. Indian Heart Journal 50(Suppl. 1): 3-4, 1998

Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. New England Journal of Medicine 367(14): 1297-1309, 2012

Ability of meat starter cultures to catabolize leucine and evaluation of the degradation products by using an HPLC method. Food microbiology 17(5): 563-570, 2000

Ranolazine Attenuates the Electrophysiological Effects of Myocardial Stretch in Langendorff-Perfused Rabbit Hearts. Cardiovascular Drugs and Therapy 29(3): 231-241, 2015

Coronary Fistulas in a Patient with a Novel Long QT Syndrome Mutation. Arquivos Brasileiros de Cardiologia 105(5): 536-539, 2015

Greater availability of dopamine transporters in patients with major depression--a dual-isotope SPECT study. Psychiatry Research 162(3): 230-235, 2008