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Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

Gupta, S.; Stravitz, R.T.; Dent, P.; Hylemon, P.B.

Journal of Biological Chemistry 276(19): 15816-15822

2001

ISSN/ISBN: 0021-9258
PMID: 11278771
DOI: 10.1074/jbc.m010878200
Accession: 010496210
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Cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the neutral pathway of bile acid biosynthesis, is feedback-inhibited at the transcriptional level by hydrophobic bile acids. Recent studies show that bile acids are physiological ligands for farnesoid X receptor (FXR). Activated FXR indirectly represses CYP7A1 transcription through induction of small heterodimer protein (SHP-1).

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Related References

Gupta, S.; Stravitz, R.Todd; Dent, P. 2001: Down-regulation of cholesterol 7a-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway Journal of Biological Chemistry 276(19): 816-822
Stravitz, R.T.; Vlahcevic, Z.R.; Gurley, E.C.; Hylemon, P.B. 1995: Repression of cholesterol 7 alpha-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes Journal of Lipid Research 36(6): 1359-1369
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