Section 11
Chapter 10,497

Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

Gupta, S.; Stravitz, R.T.; Dent, P.; Hylemon, P.B.

Journal of Biological Chemistry 276(19): 15816-15822


ISSN/ISBN: 0021-9258
PMID: 11278771
DOI: 10.1074/jbc.m010878200
Accession: 010496210

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Cholesterol 7alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the neutral pathway of bile acid biosynthesis, is feedback-inhibited at the transcriptional level by hydrophobic bile acids. Recent studies show that bile acids are physiological ligands for farnesoid X receptor (FXR). Activated FXR indirectly represses CYP7A1 transcription through induction of small heterodimer protein (SHP-1).

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