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Effect of administration of lactic acid bacteria to pregnant rats in detoxifying Trp-P1 and brain weight gain by the fetus



Effect of administration of lactic acid bacteria to pregnant rats in detoxifying Trp-P1 and brain weight gain by the fetus



Animal Science & Technology 69(11): 1050-1054



Ten weeks old wister strain pregnant rats were fed ad libitum CE-2 rat chow (Clea Japan) and water. On the 15 th days of pregnancy, 4 groups of 5 rats were each orally administered, 2 ml (i) water (control), (ii) Trp-P1 solution (25 mg/kg in 5 ml distilled water), (iii) lyophilized Leuconostoc paramesenteroides R62 cells (350 mg/kg) suspended in 5 ml Trp-P-1 solution or (iv) lyophilized R62 cells (350 mg/kg) suspended in 5 ml distilled water. The same administration was continued for three consecutive days. The brain weight of the fetus was significantly decreased by the administration of Trp-P1 (P<0.05). The administration of Trp-P1 along with R62 cells also showed decrease in brain weight of the fetus, but the decrease was comparatively less than that of the Trp-P1 group (P < 0.05). The ratio between brain weight and body weight was higher in lactic acid bacteria with Trp-P1 group than the Trp-P1 group (P<0.05).

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