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Effect of aerosolized anti-IgE (E25) on airway responses to inhaled allergen in asthmatic subjects



Effect of aerosolized anti-IgE (E25) on airway responses to inhaled allergen in asthmatic subjects



American Journal of Respiratory and Critical Care Medicine 160(3): 1023-1027



Intravenous administration of a humanized monoclonal antibody of IgE (E25) attenuates the early and late phase response to inhaled allergen in allergic asthmatic subjects. To test whether direct delivery of E25 to the airway might have the same effect, we conducted a randomized, double-blind, three group study in 33 subjects with mild allergic asthma (20 to 46 yr of age, 21 men, FEV1 > 70% predicted).

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Accession: 010516085

Download citation: RISBibTeXText

PMID: 10471635

DOI: 10.1164/ajrccm.160.3.9810012


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