EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of estrogen on the development of disuse bone atrophy induced by tail-suspension in ovariectomized rats



Effect of estrogen on the development of disuse bone atrophy induced by tail-suspension in ovariectomized rats



Environmental Medicine (Nagoya) 43(1): 19-21, December



This study evaluated how ovariectomy and estrogen administration affect the development of disuse atrophy of the hind limbs induced by tail-suspension. Five-week-old female Wistar rats were ovariectomized and divided into two groups. One group received an intramuscular injection of estradiol dipropionate once a week (OVX-E2 group), and the other received a vehicle injection (OVX group). After the third injection, the rats were subjected to tail suspension in metabolic cages for 1, 3, 5 or 7 days. Age-matched control rats not subjected to suspension were also housed individually in metabolic cages. In the OVX group, the wet weight of femurs decreased significantly after day 3 of tail-suspension. However, in the OVX-E2 group it decreased significantly only after day 7. Calcium and phosphorus contents in the femur tended to be higher in the OVX-E2 group than those in the OVX group. Alkaline phosphatase (ALP) activity, one of the markers for bone formation, did not change by tail suspension in either the OVX or OVX-E2 group. Tartrate-resistant acid phosphatase (TRAP) activity, one of the markers for bone resorption, increased significantly in the femur by tail suspension in both the OVX and OVX-E2 group. In the latter group, however, TRAP activity was constantly lower than that in the OVX group during the course of tail-suspension. Urinary excretion of deoxypyridinoline (D-Pyr) in the OVX group showed a tendency to increase on day 1 after tail-suspension. In contrast, D-Pyr excretion did not change in the OVX-E2 group at all. It was also noted that in the OVX-E2 group, D-Pyr excretion was lower than that in the OVX group. It was thus suggested that estrogen administration to OVX rats prevents the development of disuse bone atrophy through the prevention of bone resorption induced by tail-suspension.

(PDF emailed within 1 workday: $29.90)

Accession: 010522749

Download citation: RISBibTeXText



Related references

Effect of estrogen on the development of disuse atrophy of bone and muscle induced by tail-suspension in rats. Environmental Medicine (Nagoya) 41(2): 89-92, 1997

Effects of estrogen on tail suspension-induced disuse atrophy in ovariectomized rats: evaluation of the expression of interleukin-6 mRNA in the femur. Environmental Medicine 45(1): 12-14, 2002

Effect of estrogen on the development of disuse atrophy of bone and muscle induced by tail-supension in rats. Environmental Medicine 41(2): 89-92, 2001

Administration of bisphosphonate prevents disuse bone atrophy induced by tail suspension. Environmental Medicine 41(1): 16-17, 2003

Effect of estrogen and tail-suspension on expression of osteocalcin mRNA in femur of ovariectomized rats. Environmental Medicine 44(2): 82-84, 2002

A hind limb disuse model inducing extensor digitorum longus atrophy in rats: tail suspension-immobilization. Aviation, Space, and Environmental Medicine 82(7): 689-693, 2011

Effect of endurance training on disuse muscle atrophy induced by body suspension in rats A structural and biochemical study. Sato, Y , et al Medicine and Sport Science, Vol 37 Integration of medical and sports sciences; 8th International Biochemistry of Exercise Conference, Nagoya, Japan, September 24-28, 1991 xiv+446p S Karger AG: Basel, Switzerland; New York, New York, USA Illus ISBN 3-8055-5579-2 : 150-161, 1992

Changes in calcium, PTH and 1,25(OH)2 vitamin D3 during tail-suspension in ovariectomized rats: effects of estrogen administration. Environmental Medicine 44(2): 75-78, 2002

Changes in calcium, PTH and 1,25(OH)2 vitamin D3 during tail-suspension in ovariectomized rats: Effects of estrogen administration. Environmental Medicine (Nagoya) 44(2): 75-78, 2000

Bone metabolism in ovariectomized rats with induced hyperthyroidism: the effect of estrogen replacement. Chinese Journal of Physiology 49(6): 335-341, 2007

Bone metabolism in ovariectomized rats with induced hyperthyroidism: The effect of estrogen replacement. Chinese Journal of Physiology 49(6): 335-341, 2006

Tail-suspension induces altered expression of GAPDH and ZAKI-4beta mRNAs in rat hindlimbs: Implication for disuse muscle atrophy. Environmental Medicine (Nagoya) 47: 15-19, December, 2003

Leptin prevents disuse-induced bone loss in tail-suspended female rats. Journal of Bone & Mineral Research 16(Suppl 1): S143, September, 2001

Daily 4-h standing can prevent soleus atrophy induced by 4 weeks tail suspension in rats. Hang Tian Yi Xue Yu Yi Xue Gong Cheng 18(1): 12-15, 2005

The effect of high doses of fluoride on disuse atrophy of bone in young rats. Acta Pathologica et Microbiologica Scandinavica. Section A, Pathology 78(1): 49-54, 1970