+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Effects of activators used in the activated partial thromboplastin time test on its results in the tube and automated variants of the test



Effects of activators used in the activated partial thromboplastin time test on its results in the tube and automated variants of the test



Klinicheskaya Laboratornaya Diagnostika (2): 38-40



Effects of activators used in combination with partial thromboplastin (PT), manufactured by the Kirov Institute of Hematology and Blood Transfusion, on the results of the activated partial thromboplastin time (APTT) test and its sensitivity to heparin were studied. Kaolin manufactured in Russia and by Aldrich firm and silica from Sigma were used. The method was reproduced in tubes and on Organon Teknika photooptic coagulometers: semiautomatic Coag-A-Mate XM and automated Coag-A-Mate RA-4. The concentration and optical density of the activator affected the results of APTT test, which prompts the use of kits calibrated for the PT/activator combination but not separate reagents. Combination of PT manufactured by the Kirov Institute and suspension of Russian kaolin ensured high sensitivity of the method to heparin content in the plasma and good reproducibility of the method both in tubes and on Organon Teknika coagulometers: coefficient of variation of APTT in all variants of the tube test were no higher than 10% and in the automated variant 2.6-6.2%.

(PDF emailed within 1 workday: $29.90)

Accession: 010544074

Download citation: RISBibTeXText


Related references

Effect of activators for activated partial thromboplastin time test on its results in the tube and automated test versions. Klinicheskaia Laboratornaia Diagnostika: 38-40, 2002

Coagulation factors V, VIII, and X, prothrombin time and activated partial thromboplastin time test results in thawed plasma stored at 1-6 ºC for 5 days. Blood Transfusion 9(1): 95-98, 2011

Effects of platelets and platelet-derived material on the activated partial thromboplastin time (Cephotest) coagulation test. Scandinavian Journal of Clinical and Laboratory Investigation 65(4): 321-332, 2005

The PiCT ® test is a reliable alternative to the activated partial thromboplastin time in unfractionated heparin therapy management: results from a multicenter study. Journal of Thrombosis and Haemostasis 14(11): 2187-2193, 2016

Patient's age and the activated partial thromboplastin time test. Thrombosis and Haemostasis 39(3): 780-781, 1978

Activated partial thromboplastin time (APTT). New indications for an old test?. Journal of Thrombosis and Haemostasis 4(4): 750-751, 2006

Detection of inhibitors using the activated partial thromboplastin time test. British Journal of Haematology 61(3): 565, 1985

Use of fractionated soy phospholipids in a test of activated partial thromboplastin time. Gematologiia i Transfuziologiia 40(4): 36-38, 1995

Studies on blood coagulation in the dog and horse. Retraction, heparin tolerance test, thromboplastin time, thrombin time, prothrombin consumption test, thromboplastin generation test, factor X, thrombocyte count. Untersuchungen uber die Blutgerinnung bei Hund und Pferd Retraktion, Heparintoleranztest, Thromboplastinzeit, Thrombinzeit, Prothrombinverbrauchstest, Thromboplastingenerationstest, Faktor X, Thrombozytenzahl: 71, 1973

Activated partial thromboplastin time test in heparin therapy. A study. Missouri Medicine 66(6): 430-433, 1969

Test for detection of activated partial thromboplastin time using ellagic acid. Klinicheskaia Laboratornaia Diagnostika: 18-20, 1999

Analysis of the activated partial thromboplastin time test using mathematical modeling. Thrombosis Research 101(4): 299-310, February 15, 2001

Soya bean fractionated phospholipids in activated partial thromboplastin time test. Gematologiya i Transfuziologiya 40(4): 36-38, 1995

Stability of activated partial thromboplastin time (APTT) test under different storage conditions. Hematology 11(5): 311-315, 2007