+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Effects of acute restraint stress on endogenous adrenomedullin levels



Effects of acute restraint stress on endogenous adrenomedullin levels



Neuroreport 10(13): 2829-2833



Adrenomedullin (ADM) is a 52 amino acid peptide, with a potent hypotensive/vasodilatory action. Levels of ADM are significantly elevated in patients with hypertension, and it has been postulated that such stressor-related increases may serve a regulatory or protective function. The current study assessed the effects of acute restraint stress on ADM levels in regions of the brain, plasma and peripheral tissue including heart, lung and the adrenal glands of rats. This stressor, known to stimulate sympathetic activity as well as the hypothalamic-pituitary adrenal (HPA) axis, produced a significant increase in ADM levels in the pituitary gland, plasma and adrenal glands, all of which are key components of the HPA axis. The results suggest a regulatory and/or protective role for ADM in countering HPA activation following a variety of physiological and psychological stressors.

(PDF emailed within 0-6 h: $19.90)

Accession: 010544255

Download citation: RISBibTeXText

PMID: 10511448

DOI: 10.1097/00001756-199909090-00024


Related references

Restraint stress and acute ethanol administration alter endogenous levels of a neuroactive steroid. Society for Neuroscience Abstracts 21(1-3): 1949, 1995

Adrenomedullin distribution in brain, peripheral tissue and plasma following acute restraint stress. Society for Neuroscience Abstracts 24(1-2): 1921, 1998

Polyamine levels in brain and plasma after acute restraint or water-immersion restraint stress in mice. Neuroscience Letters 355(1-2): 57-60, 2004

Effects of acute restraint stress, prolonged captivity stress and transdermal corticosterone application on immunocompetence and plasma levels of corticosterone on the cururu Toad (Rhinella icterica). Plos One 10(4): E0121005-E0121005, 2016

The effects of restraint stress on the neuropathogenesis of Theiler's virus infection II: NK cell function and cytokine levels in acute disease. Brain, Behavior, and Immunity 18(2): 166-174, 2004

The effect of acute restraint stress on regional brain neurotransmitter levels in stress-susceptible Pietrain pigs. Journal of Veterinary Medicine Series A 47(5): 257-269, 2000

Repeated restraint stress prevents changes in corticotropin-releasing factor binding protein mRNA induced by acute restraint stress. Society for Neuroscience Abstracts 26(1-2): Abstract No -851 9, 2000

Acute effects of endothelins on endogenous adrenomedullin system in the rat heart: Immunocytochemical and autoradiographic studies. International Journal of Molecular Medicine 13(5): 669-674, 2004

Clamped Corticosterone (B) Reveals the Effect of Endogenous B on Both Facilitated Responsivity to Acute Restraint and Metabolic Responses to Chronic Stress. Stress 1(1): 33-49, 1996

The Effects of Acute Restraint Stress on Plasma Levels of Prolactin and Corticosterone across Life-History Stages in a Short-Lived Bird: Gambel's White-Crowned Sparrow (Zonotrichia leucophrys gambelii). Physiological and Biochemical Zoology 88(6): 589-598, 2016

The Atypical Antipsychotic Paliperidone Regulates Endogenous Antioxidant/Anti-Inflammatory Pathways in Rat Models of Acute and Chronic Restraint Stress. Neurotherapeutics 13(4): 833-843, 2016

Effects of stress transmission pathways of acute ulcerogenesis in rats under cold restraint stress. Hiroshima Journal of Medical Sciences 37(2): 57-62, 1988

Catecholamines and 5-hydroxytryptamine levels in the pig brain: the effect of acute restraint stress. Animal Science Papers and Reports Polish Academy of Sciences, Institute of Genetics and Animal Breeding Jastrzebiec 13(4): 283-289, 1995

Effects of acute restraint stress, chronic swim stress and glutamine administration on the release of superoxide from alveolar macrophages of rats. Revista de Nutricao 20(4): 387-396, 2007

Diazepam attenuation of restraint stress-induced corticosterone levels is enhanced by prior exposure to repeated restraint. Psychoneuroendocrinology. 22(5): 349-360, 1997