+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Effects of adding steroids, in vitro irradiation, or both to cyclosporine immunosuppression in the murine laryngeal transplantation model

Effects of adding steroids, in vitro irradiation, or both to cyclosporine immunosuppression in the murine laryngeal transplantation model

Annals of Otology, Rhinology, and Laryngology 111(5 Pt 1): 455-459

Adding oral prednisone or in vitro organ irradiation to an immunosuppressive regimen for laryngeal transplantation may allow cyclosporine dosage to be decreased without compromising organ rejection rates. Using an established rat laryngeal transplant model, we sought to determine whether combined immunosuppressive regimens decreased rejection rates. Twenty-two treatment groups of 10 animals each were studied. Cyclosporine was administered at 2 different historically low dosages (1.5 and 2 mg/kg per day) alone, in combination with prednisone, and with in vitro irradiation of the harvested larynx. At 15 days after transplantation, cyclosporine combined with prednisone did not significantly alter the mean severity of rejection. At 30 days after transplantation, rats treated with a combination of cyclosporine 2 mg/kg and prednisone 1 mg/kg showed the least amount of rejection. Rejection rates were significantly higher with 2 mg/kg cyclosporine alone (p < .00024). Irradiation did not significantly decrease the severity of rejection. These results demonstrate that at 1 month after transplantation, a combined steroid and cyclosporine regimen reduces the severity of rejection after laryngeal transplantation in an animal model. Our findings suggest that laryngeal transplant patients may be treated with low cyclosporine doses without experiencing organ rejection if steroids are added to the immunosuppressive regimen.

(PDF emailed within 0-6 h: $19.90)

Accession: 010544303

Download citation: RISBibTeXText

PMID: 12019516

DOI: 10.1177/000348940211100511

Related references

Effect of in vitro irradiation of donor larynges on cyclosporine requirements and rejection rates in rat laryngeal transplantation. Annals of Otology, Rhinology, and Laryngology 110(1): 20-24, 2001

Immunosuppressive effect of irradiation in the murine laryngeal transplantation model: a controlled trial. Annals of Otology, Rhinology, and Laryngology 112(8): 712-715, 2003

Immunosuppression with low-dose cyclosporine, mizoribine, and steroids in living-related kidney transplantation. Transplantation Proceedings 26(4): 1907-1909, 1994

Two-year results of a prospective randomized comparison of cyclosporine/low dose steroid immunosuppression with azathioprine and steroids in renal transplantation. Transplantation Proceedings 19(1 Pt 3): 1852-1852, 1987

A randomized trial comparing cyclosporine and steroids with cyclosporine, azathioprine, and steroids in cadaveric renal transplantation. Transplantation 65(5): 653-661, 1998

Low dose steroids do not augment cyclosporine immunosuppression but do diminish cyclosporine nephrotoxicity. Transplantation Proceedings 17(1 PART 2): 1289-1290, 1985

Cyclosporine A versus tacrolimus in combination with mycophenolate mofetil and steroids as primary immunosuppression after lung transplantation: one-year results of a 2-center prospective randomized trial. Journal of Thoracic and Cardiovascular Surgery 125(4): 891-900, 2003

Immunosuppression by combined use of cyclosporine and resveratrol in a rat liver transplantation model. Transplantation Proceedings 37(5): 2354-2359, 2005

Postgrafting immunosuppression with sirolimus and cyclosporine facilitates stable mixed hematopoietic chimerism in dogs given sublethal total body irradiation before marrow transplantation from DLA-identical littermates. Biology of Blood and Marrow Transplantation 9(8): 489-495, 2003

The Correct Sequence of Treatment for Pediatric Inflammatory Bowel Disease (IBD)-Nutrition or Steroids and/or Immunosuppression? Steroids and/or Immunosuppression! Nutrition Is to Grow, Steroids and/or Immunosuppression Are to Heal. Inflammatory Bowel Diseases 3(1): 54-57, 1997

Nephrotoxic effects of primary immunosuppression with FK-506 and cyclosporine regimens after liver transplantation. O Clinic Proceedings. 69(2): 105-111, 1994

Azathioprine cyclosporine or cyclosporine immunosuppression after pediatric heart transplantation mid term results. Journal of the American College of Cardiology 19(3 SUPPL A): 204A, 1992

Effects of immunosuppression induced by thalidomide and cyclosporine in heterotopic heart transplantation in rabbits. Transplantation Proceedings 39(5): 1640-1641, 2007

Cyclosporine dose, serum trough levels, and allograft preservation in a rat model of laryngeal transplantation. Annals of Otology, Rhinology, and Laryngology 112(6): 506-510, 2003

Long-term effects of cyclosporine-based immunosuppression in cardiac transplantation: the Loyola experience. Transplantation Proceedings 22(3 Suppl 1): 6-11, 1990