+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Effects of aging and subsequent exercise training on gene expression of endothelin-1 in rat heart



Effects of aging and subsequent exercise training on gene expression of endothelin-1 in rat heart



Clinical Science 103 Suppl 48: 152s-157s



Endothelin-1 (ET-1) is produced by endothelial cells and cardiac myocytes. ET-1 has potent positive inotropic and chronotropic effects on heart and induces myocardial cell hypertrophy. We investigated whether gene expression of ET-1 in rat hearts is altered by aging and subsequent exercise training. We also investigated whether gene expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which participate in some pathological cardiac conditions, in the rat hearts is altered by aging and subsequent exercise training. We studied mRNA expression of ET-1, ANP and BNP in hearts of sedentary young rats (Sedentary young; 4 months old), sedentary aged rats (Sedentary aged; 23 months old), and swim-trained aged rats (Trained aged; 23 months old, swimming training for 8 weeks). The left ventricle weight mass index for body weight and left ventricular end-diastolic dimension were significantly higher in the Trained aged group compared with the Sedentary aged group. These results showed that Trained aged rats developed cardiac hypertrophy with improvement of cardiac function. The mRNA expression of ET-1 in the heart was significantly higher in Sedentary aged group compared with Sedentary young group, and was significantly higher in the Trained aged group compared with the Sedentary aged group. The mRNA expression of ANP and BNP in the heart was significantly higher in Sedentary aged group compared with Sedentary young group, and was significantly higher in the Trained aged group compared with the Sedentary aged group. The present results show that mRNA expression of ET-1 in the heart is increased by aging, and that the mRNA expression is further increased by exercise-induced cardiac hypertrophy, suggesting that ET-1 in the heart may participate in these physiological cardiac adaptations.

(PDF emailed within 0-6 h: $19.90)

Accession: 010544677

Download citation: RISBibTeXText

PMID: 12193075

DOI: 10.1042/CS103S152S


Related references

The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles. Cardiovascular Research 66(2): 393-401, 2005

Chronic heart failure and aging - effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study. European Journal of Preventive Cardiology 23(4): 349-358, 2016

Time course alteration of endothelin-1 gene expression in the heart during exercise and recovery from post-exercise periods in rats. Journal of Cardiovascular Pharmacology 44 Suppl 1: S447-S450, 2005

Time course alteration of endothelin-1 gene expression in the heart during exercise and recovery from post-exercise periods in rats. Journal of Cardiovascular Pharmacology 44(Suppl. 1): S447-S450, 2004

Effects of gradual coronary artery occlusion and exercise training on gene expression in swine heart. Molecular and Cellular Biochemistry 294(1-2): 87-96, 2006

Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging catabolism study. Circulation 125(22): 2716-2727, 2012

Effects of exercise training and feeding on lipoprotein lipase gene expression in adipose tissue, heart, and skeletal muscle of the rat. Metabolism Clinical & Experimental. 44(12): 1596-1605, 1995

Effects of aging and exercise training on apoptosis in the heart. Journal of Exercise Rehabilitation 9(2): 212-219, 2013

Changes in muscle mitochondrial gene expression with aging and aerobic exercise training. FASEB Journal 17(4-5): Abstract No 813 7, March, 2003

Effects of exercise training on expression of endothelin-1 mRNA in the aorta of aged rats. Clinical Science 103 Suppl 48: 118s-123s, 2002

Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study. European Heart Journal 33(14): 1758-1768, 2012

Effects of aging and exercise training on iNOS protein expression in skeletal muscle. Medicine & Science in Sports & Exercise 34(5 Supplement): S189, 2002

Expression of phospholemman and its association with Na+-K+-ATPase in skeletal muscle: effects of aging and exercise training. Journal of Applied Physiology 99(4): 1508-1515, 2005

Antiaging effect of exercise training on the rat heart Gene expression profile approach. Journal of the American College of Cardiology 39(5 Supplement A): 139A, March 6, 2002

Effect of aging on gene expression rates of endothelin-1 and endothelin-2/vasoactive intestinal contractor in ethanol-induced gastric mucosal injury of the mouse. Clinical Science 103 Suppl 48: 455s-458s, 2002