+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Effects of aging on central conduction in somatosensory evoked potentials: Evaluation of onset versus peak methods

Effects of aging on central conduction in somatosensory evoked potentials: Evaluation of onset versus peak methods

Clinical Neurophysiology 110(12): 2094-2103

Objectives: To investigate effects of aging on peripheral and central somatosensory conduction, and evaluate onset-to-onset and peak-to-peak measurements of each component and central conduction time (CCT) in somatosensory evoked potentials (SEPs). Methods: We recorded SEPs with non-cephalic reference from the Erb's point, the posterior (cv 6) and anterior neck, and scalp (Fz and P4) after left median nerve stimulation in 138 normal subjects aged between 20 and 78 years. We determined onset or peak latencies of the Erb's potential (N9), the spinal N13-P13 in cv 6-to-anterior neck montage and the N20-P20 in scalp leads. Onset CCT was defined as a transit time from N13-P13 onset to N20-P20 onset. In each subject, interpeak latencies of the 'N13' component in cv 6-to-Fz montage and the N20-P20 in P4-to-Fz montage were also defined as conventional peak CCT. Results: Using multiregression analysis, we found that the onset or peak latencies of each SEP component were correlated with the subject's height and age. So were the onset CCTs: Onset CCT (in ms) = 2.549 + 2.041 X (height in meters) + 0.005 X (age in years) (P < 0.0001). The conventional peak CCTs as well as onset-to-peak durations of the N20-P20 were correlated with the subject's age but not height: Peak CCT(in ms) = 5.458 + 0.012 X (age in years) (P < 0.0005). Conclusion: Conductive function is affected by normal aging in the central as well as peripheral somatosensory pathways. The peak CCT is more affected by aging than the onset CCT. However, the onset-to-peak duration of the N20-P20 increased by 0.8 ms between the 4th and 7th decades, suggesting that the peak CCT increase in older people reflects the age-related changes in N20-P20 profile but not in the fastest central conduction. We therefore conclude that the onset CCT measurement is preferable to the peak CCT measurement when assessing the central somatosensory conduction.

(PDF emailed within 0-6 h: $19.90)

Accession: 010544690

Download citation: RISBibTeXText

DOI: 10.1016/s1388-2457(99)00193-5

Related references

Effects of aging on central conduction in somatosensory evoked potentials: evaluation of onset versus peak methods. Clinical Neurophysiology 110(12): 2094-2103, 2000

Central conduction in somatosensory evoked potentials: comparison of ulnar and median data and evaluation of onset versus peak methods. Neurology 47(5): 1299-1304, 1996

Median and tibial nerve somatosensory evoked potentials evaluation of central conduction time in multiple sclerosis. Muscle & Nerve 7(7): 583, 1984

Somatosensory central conduction time in cervical spondylotic myelopathy Onset-to-onset measurement vs peak-to-peak measurement. European Journal of Neurology 7(Supplement 3): 131, November, 2000

Central somatosensory conduction time and short latency somatosensory evoked potentials in post-traumatic coma. Electroencephalography and Clinical Neurophysiology 56(6): 583-596, 1983

Stability of N20 onset or peak latency in median somatosensory evoked potentials. Muscle & Nerve 23(2): 278-282, 2000

Median nerve conduction velocity and central conduction time measured with somatosensory evoked potentials in thyroxine-treated infants with Down syndrome. Pediatrics 118(3): E825-E832, 2006

Delayed central conduction of somatosensory evoked potentials in xeroderma pigmentosum. Neurology 41(6): 933-935, 1991

High spinal anesthesia does not depress central nervous system function as measured by central conduction time and somatosensory evoked potentials. Anesthesia and Analgesia 71(2): 176-180, 1990

The central conduction time in posterior tibial and pudendal nerve somatosensory evoked potentials. Yonsei Medical Journal 42(1): 9-13, 2001

Peripheral nerve conduction visual evoked potentials somatosensory evoked potentials and vitamin b 1 serum level in chronic alcoholics. Electroencephalography & Clinical Neurophysiology 58(5): 107P, 1984

Somatosensory evoked potentials and central motor pathways conduction after magnetic stimulation of the brain in diabetes. Electromyography and Clinical Neurophysiology 35(7): 443-448, 1995

Determination of conduction times of the peripheral and central parts of the sensory pathway using evoked somatosensory potentials. Acta Physiologica Polonica 36(3): 216-223, 1985

Peripheral and central somatosensory pathways and evoked cerebral potentials during aging. Revue D'electroencephalographie et de Neurophysiologie Clinique 10(2): 146-152, 1980