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Effects of alcohol and cholesterol feeding on lipoprotein metabolism and cholesterol absorption in rabbits



Effects of alcohol and cholesterol feeding on lipoprotein metabolism and cholesterol absorption in rabbits



Arteriosclerosis, Thrombosis, and Vascular Biology 19(3): 598-604



Alcohol fed to rabbits in a liquid formula at 30% of calories increased plasma cholesterol by 36% in the absence of dietary cholesterol and by 40% in the presence of a 0.5% cholesterol diet. The increase was caused almost entirely by VLDL, IDL, and LDL. Cholesterol feeding decreased the fractional catabolic rate for VLDL and LDL apoprotein by 80% and 57%, respectively, and increased the production rate of VLDL and LDL apoprotein by 75% and 15%, respectively. Alcohol feeding had no effect on VLDL apoprotein production but increased LDL production rate by 55%. The efficiency of intestinal cholesterol absorption was increased by alcohol. In the presence of dietary cholesterol, percent cholesterol absorption rose from 34.4+/-2.6% to 44.9+/-2.5% and in the absence of dietary cholesterol, from 84.3+/-1.4% to 88.9+/-1.0%. Increased cholesterol absorption and increased LDL production rate may be important mechanisms for exacerbation by alcohol of hypercholesterolemia in the cholesterol-fed rabbit model.

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Accession: 010544824

Download citation: RISBibTeXText

PMID: 10073962

DOI: 10.1161/01.ATV.19.3.598


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