EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Effects of lentinan on colorectal carcinogenesis in mice with ulcerative colitis



Effects of lentinan on colorectal carcinogenesis in mice with ulcerative colitis



Oncology Reports 7(3): 599-601



Lentinan; i.e., polysaccharides extracted from a kind of black mushroom shiitake, has been clinically applied as an antitumor and antimetastatic drug, and has been reported to prevent both chemical and viral carcinogenesis. It is known that lentinan affects the tumorous vascular system resulting in the induction of hemorrhagic necrosis which is dependent on T-cells in the tumor. Repeated mucosal necrosis-regeneration sequence in chronic ulcerative colitis induced with 3% dextran sulfate sodium led to colorectal carcinogenesis in azoxymethane-pretreated mice. In the present study, the additive treatment with lentinan in the azoxymethane-dextran sulfate sodium treated mice enhanced the colorectal high-grade dysplasia, though not significantly, and the splenic weight. This may show the proliferation of pathogenic splenic T cells resulting in a change for the worse of ulcerative colitis, anemia induced with hemorrhage and colorectal carcinogenesis; i.e., high-grade dysplasia of the mucosa and/or invasive adenocarcinomas of the colorectum. The present results may recommend chemoimmunotherapy while using lentinan, but not immunotherapy using lentinan alone, is indicated for the management of cancer patients.

(PDF emailed within 0-6 h: $19.90)

Accession: 010556344

Download citation: RISBibTeXText

PMID: 10767375

DOI: 10.3892/or.7.3.599



Related references

Preventive effects of sulphasalazine on colorectal carcinogenesis in mice with ulcerative colitis. In Vivo 14(3): 463-466, 2000

Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Cancer Epidemiology, Biomarkers & Prevention 12(11 Pt 1): 1262-1267, 2003

Ibadronate may prevent colorectal carcinogenesis in mice with ulcerative colitis. Anticancer Research 29(11): 4615-4619, 2010

The more an ulcerative colitis is repeated, the more the risk of colorectal carcinogenesis is increased in mice. Anticancer Research 22(6c): 3955-3961, 2003

Chemopreventive effect of a vitamin D(3) analog, alfacalcidol, on colorectal carcinogenesis in mice with ulcerative colitis. Anti-Cancer Drugs 18(10): 1183-1187, 2007

Inducible nitric oxide synthase -deficient mice are not protected from chronic ulcerative colitis -associated colorectal carcinogenesis. Proceedings of the American Association for Cancer Research Annual Meeting 43: 12, March, 2002

Inflammation and colorectal carcinogenesis including carcinogenesis of ulcerative colitis. Nihon Rinsho. Japanese Journal of Clinical Medicine 69 Suppl 3: 121-125, 2012

Effects of dietary folate on colorectal carcinogenesis in a genetically-predisposed murine model of ulcerative colitis-associated colon cancer. Gastroenterology 120(5 Supplement 1): A 447, April, 2001

Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis. Cancer Research 62(4): 1148-1151, 2002

Inhibition of chronic ulcerative colitis -associated carcinogenesis in mice by N-acetyl-L-cysteine Effects on oxidative/nitrosative damage and proliferation. Proceedings of the American Association for Cancer Research Annual Meeting 42: 866, March, 2001

Metallothionein: early marker in the carcinogenesis of ulcerative colitis-associated colorectal carcinoma. World Journal of Surgery 26(6): 726-731, 2002

Metallothionein An early marker in the carcinogenesis of ulcerative colitis-associated colorectal carcinoma. Gastroenterology 118(4 Suppl 2 Part 2): AGA A1382, April, 2000

Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR Mice. Evidence-Based Complementary and Alternative Medicine 2012: 820415-820415, 2013

Epithelial markers of colorectal carcinogenesis in ulcerative colitis and primary sclerosing cholangitis. World Journal of Gastroenterology 19(14): 2234-2241, 2013

Therapeutic effect of nimesulide on colorectal carcinogenesis in experimental murine ulcerative colitis. Journal of Gastroenterology and Hepatology 22(9): 1474-1481, 2007