+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of neomycin on the development of tolerance to morphine antinociception



Effects of neomycin on the development of tolerance to morphine antinociception



Life Sciences 69(18): 2081-2090



The effects of neomycin on the development of tolerance to morphine antinociception were examined in mice. Because neomycin did not readly cross blood brain barrier, we examined the effects of neomycin following systemic, intracerebroventricular (i.c.v.) and intrathecal (i.t.) injections on the morphine tolerance. Daily subcutaneous (s.c.), i.c.v. and i.t. injections of morphine produced tolerance regardless of route of administration. Both i.c.v. and i.t. neomycin, which alone produced no changes in the basal tail flick latencies, significantly attenuated the development of tolerance to antinociception produced by repeated systemic morphine, while intraperitoneal (i.p.) administration of neomycin did not affect morphine tolerance. Further, i.c.v. and i.t. neomycin attenuated the development of tolerance to antinociception produced by repeated i.c.v. and i.t. morphine, respectively, which were not attenuated by systemic neomycin. This results indicate a potential role for neomycin-sensitive Ca2+ channels on the development of tolerance to the morphine antinoception.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010558568

Download citation: RISBibTeXText

PMID: 11669452

DOI: 10.1016/s0024-3205(01)01275-9


Related references

Chimeric peptide of Met-enkephalin and FMRFa induces antinociception and attenuates development of tolerance to morphine antinociception. Peptides (New York) 20(4): 471-478, 1999

Suppressive effects of lamotrigine on the development and expression of tolerance to morphine-induced antinociception in the male mouse. Brain Research 1291: 32-39, 2009

B Vitamins Potentiate Acute Morphine Antinociception and Attenuate the Development of Tolerance to Chronic Morphine in Mice. Pain Medicine 18(10): 1961-1974, 2017

Molecular mechanisms of the development of tolerance to morphine-induced antinociception following repeated treatment with morphine in the mouse spinal cord. Proceedings of the Hoshi University 48: 33-41, 2006

The effects of intraperitoneal administration of antagonists and development of morphine tolerance on the antinociception induced by stimulating the anterior pretectal nucleus of the rat. British Journal of Pharmacology 92(4): 769-780, 1987

Effects of haloperidol on morphine induced antinociception morphine tolerance and withdrawal in hyperprolactinemic rats. Neuropharmacology 24(11): 1027-1032, 1985

Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance. Journal of Pharmacology and Experimental Therapeutics 297(1): 446-457, 2001

Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals 28(2): 236-244, 2000

Intrathecal Zn2+ attenuates morphine antinociception and the development of acute tolerance. European Journal of Pharmacology 407(3): 267-272, 3 November, 2000

Zimelidine attenuates the development of tolerance to morphine-induced antinociception. Indian Journal of Pharmacology 44(2): 215-218, 2012

Effect of chemical sympathectomy on morphine antinociception and tolerance development in the rat. Biochemical Pharmacology 22(21): 2769-2772, 1973

Cysteine protease inhibitors suppress the development of tolerance to morphine antinociception. Neuropeptides 42(3): 239-244, 2008

Development of tolerance to morphine antinociception in mice treated with nociceptive stimulants. Japanese Journal of Pharmacology 63(1): 59-64, 1993

Morphine and dipyrone co-administration delays tolerance development and potentiates antinociception. European Journal of Pharmacology 469(1-3): 71-79, 2003

Influence of gossypin on the development of acute tolerance to morphine induced antinociception. Indian Journal of Experimental Biology 35(4): 413-414, 1997