Home
  >  
Section 11
  >  
Chapter 10,560

Effects of ovarian hormones and environment on radial maze and water maze performance of female rats

Daniel, J.M.; Roberts, S.L.; Dohanich, G.P.

Physiology and Behavior 66(1): 11-20

1999

ISSN/ISBN: 0031-9384
PMID: 10222467
DOI: 10.1016/s0031-9384(98)00272-8
Accession: 010559636
Download citation:  
Text
  |  
BibTeX
  |  
RIS
The effects of gonadal hormones and environment on performance in an eight-arm radial maze and in the Morris water maze were determined in female rats. Long-Evans female rats were ovariectomized or sham ovariectomized at 35 days of age, and housed in complex environments or in isolation for the duration of the study. One month following surgeries, spatial working memory performance in the radial maze was assessed. Exposure to complex environmental conditions independently enhanced performance, as indicated by increased arm choice accuracy during 20 days of maze training. Additionally, gonadally intact females significantly outperformed ovariectomized females before cyclicity was disrupted by food deprivation. Following radial maze training, spatial reference memory performance was assessed in the same females utilizing the Morris water maze. Gonadally intact females housed in isolation performed significantly more poorly during 16 days of place training trials and displayed significantly shorter times in the platform quadrants and fewer target crossings during probe trials than gonadally intact and ovariectomized females housed in complex environments and ovariectomized rats housed in isolation. Consequently, acquisition and retention of the water maze was impaired by the presence of ovaries, and this impairment was counteracted by exposure to complex environments. Performance did not differ between groups on cued trials, indicating that sensorimotor and motivational functions did not differ between groups. Results of these experiments indicate that endogenous gonadal hormones can differentially affect performance on tasks of spatial working and spatial reference memory, and that environmental conditions can interact with gonadal hormones to affect behavior.

PDF emailed within 0-6 h: $19.90




Related References

Uchikoshi, K.; Ogura, H.; Furuya, Y.; Yamanishi, Y. 1993: Effects of medial septal lesion on the performance of rats in water maze and radial maze Japanese Journal of Pharmacology 61(Suppl 1): 186P
Shif, O.; Gillette, K.; Damkaoutis, C.M.; Carrano, C.; Robbins, S.J.; Hoffman, J.R. 2006: Effects of Ginkgo biloba administered after spatial learning on water maze and radial arm maze performance in young adult rats Pharmacology Biochemistry and Behavior 84(1): 17-25
Ormerod, B.K.; Beninger, R.J. 2002: Water maze versus radial maze: differential performance of rats in a spatial delayed match-to-position task and response to scopolamine Behavioural Brain Research 128(2): 139-152
Suenaga, T.; Kaku, M.; Ichitani, Y. 2008: Effects of intrahippocampal cannabinoid receptor agonist and antagonist on radial maze and T-maze delayed alternation performance in rats Pharmacology Biochemistry and Behavior 91(1): 91-96
Bindu, B.; Rekha, J.; Kutty, B.M. 2005: Post insult enriched housing improves the 8-arm radial maze performance but not the Morris water maze task in ventral subicular lesioned rats Brain Research 1063(2): 121-131
Dudchenko, P.A.; Goodridge, J.P.; Seiterle, D.A.; Taube, J.S. 1997: Effects of repeated disorientation on the acquisition of spatial tasks in rats: dissociation between the appetitive radial arm maze and aversive water maze Journal of Experimental Psychology. Animal Behavior Processes 23(2): 194-210
Mutlu, O.; Akar, F.; Celikyurt, I.K.; Tanyeri, P.; Ulak, G.; Erden, F. 2015: 7-Ni and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice Drug Target Insights 9: 1-8
Beninger, R.J.; Tuerke, K.J.; Forsyth, J.K.; Giles, A.; Xue, L.; Boegman, R.J.; Jhamandas, K. 2009: Neonatal ventral hippocampal lesions in male and female rats: effects on water maze, locomotor activity, plus-maze and prefrontal cortical GABA and glutamate release in adulthood Behavioural Brain Research 202(2): 198-209
Zhang, J.-X.; Chen, X.-Q.; Du, J.-Z.; Chen, Q.-M.; Zhu, C.-Y. 2005: Neonatal exposure to intermittent hypoxia enhances mice performance in water maze and 8-arm radial maze tasks Journal of Neurobiology 65(1): 72-84
Enomoto, T.; Ishibashi, T.; Tokuda, K.; Ishiyama, T.; Toma, S.; Ito, A. 2008: Lurasidone reverses MK-801-induced impairment of learning and memory in the Morris water maze and radial-arm maze tests in rats Behavioural Brain Research 186(2): 197-207
Sato, T.; Tanaka, K.-I.; Ohnishi, Y.; Teramoto, T.; Irifune, M.; Nishikawa, T. 2004: Effects of estradiol and progesterone on radial maze performance in middle-aged female rats fed a low-calcium diet Behavioural Brain Research 150(1-2): 33-42
Matsuoka, N.; Maeda, N.; Yamazaki, M.; Ohkubo, Y.; Yamaguchi, I. 1992: Effect of FR121196, a novel cognitive enhancer, on the memory impairment of rats in passive avoidance, water maze and radial arm maze tasks Society for Neuroscience Abstracts 18(1-2): 341
Dornan, W.A.; Mccampbell, A.R.; Tinkler, G.P.; Hickman, L.J.; Bannon, A.W.; Decker, M.W.; Gunther, K.L. 1997: Comparison of site specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin Behav. Brain Res 86(2): 181-189
Dornan, W.A.; McCampbell, A.R.; Tinkler, G.P.; Hickman, L.J.; Bannon, A.W.; Decker, M.W.; Gunther, K.L. 1997: Comparison of site specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin Behavioural Brain Research 86(2): 181-189
Dornan, W.A.; Mccampbell, A.R.; Tinkler, G.P.; Hickman, L.J.; Bannon, A.W.; Decker, M.W.; Gunther, K.L. 1996: Comparison of site-specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin Behavioural Brain Research 82(1): 93-101
Bartolomeo, A.C.; Moyer, J.A.; Muth, E.A.; Boast, C.A. 1995: Long-term effects of ovariectomies in female rats on radial arm maze performance using longitudinal and cross-sectional designs Society for Neuroscience Abstracts 21(1-3): 1898
Levin, E.D.; Christopher, N.C.; Briggs, S.J. 1994: Comparison of chronic nicotine and mecamylamine effects of working memory performance in the radial-arm maze and T-maze alternation Society for Neuroscience Abstracts 20(1-2): 151
Michael, F. Brown 1990: The effects of maze-arm length on performance in the radial-arm maze Learning and Behavior 18(1): 13-22
Buresová, O.; Bolhuis, J.J.; Bures, J. 1986: Differential effects of cholinergic blockade on performance of rats in the water tank navigation task and in a radial water maze Behavioral Neuroscience 100(4): 476-482
Akar, F.; Mutlu, O.; Celikyurt, I.K.; Ulak, G.; Erden, F.; Bektas, E.; Tanyeri, P. 2015: Effects of rolipram and zaprinast on learning and memory in the Morris water maze and radial arm maze tests in naive mice Drug Research 65(2): 86-90