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Efficacy and safety of sildenafil citrate in the treatment of men with mild to moderate erectile dysfunction



Efficacy and safety of sildenafil citrate in the treatment of men with mild to moderate erectile dysfunction



British Journal of Psychiatry 178(April): 325-330, April



Background: Erectile dysfunction is a common, multi-factorial disorder. Aims: To evaluate the efficacy, tolerability and frequency of use of sildenafil citrate in men with mild to moderate erectile dysfunction of no established organic cause. Method: This double-blind, randomised, placebo-controlled, flexible-dose, two-way crossover study was conducted at four centres in the UK in 44 men with mild to moderate erectile dysfunction of no clinically obvious organic cause. The study included two 28-day treatment periods, during which time sildenafil or placebo (25-75 mg, based on efficacy) was taken as required. Results: Compared with placebo, sildenafil was associated with increases increases in frequency of use, erections adequate for sexual intercourse and level of sexual satisfaction (P < 0.0001). More patients receiving sildenafil stated they would use the treatment again compared with those receiving placebo (P < 0.0001). There were no discontinuations due to sildenafil treatment. Conclusions: Sildenafil is effective and well tolerated in men with mild to moderate erectile dysfunction of no clinically identifiable organic cause.

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Accession: 010569288

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PMID: 11282811

DOI: 10.1192/bjp.178.4.325



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