Elevation of serum 17-beta-estradiol in channel catfish following injection of 17-beta-estradiol, ethynyl estradiol, estrone, estriol and estradiol-17-beta-glucuronide

Tilton, F.; Benson, W.H..; Schlenk, D.

Environmental Toxicology and Pharmacology 9(4): 169-172

2001


ISSN/ISBN: 1382-6689
PMID: 11292580
Accession: 010579090

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Abstract
17-beta-Estradiol is naturally converted in numerous organisms to various derivatives/metabolites, which may be excreted from the organism into its immediate external environment. There is a paucity of data regarding the biological effects of these derivatives/metabolites on aquatic organisms. Male channel catfish (200-500 g, N = 5, 12-18 months) were injected with 1 mg/kg 17-beta-estradiol (E2), ethynyl estradiol (EE2), estrone, estriol or E2-17-beta-glucuronide with subsequent measurements of vitellogenin (Vtg) and serum E2 concentrations 7 days post injection. EE2 and E2 gave the largest magnitude of Vtg response followed by estrone and estriol. Exposure to EE2, estrone, and E2-17-beta-glucuronide all induced significant increases in serum E2 concentrations. This study indicates that metabolites of E2 are also estrogenic and may potentially disrupt estrogen feedback loops within aquatic organisms.