EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Endoscopic detection of transitional cell carcinoma with 5-aminolevulinic acid: Results of 1012 fluorescence endoscopies



Endoscopic detection of transitional cell carcinoma with 5-aminolevulinic acid: Results of 1012 fluorescence endoscopies



Urology 57(4): 690-694, April



Objectives: The initial encouraging results using 5-aminolevulinic acid (5-ALA) induced fluorescence endoscopy (AFE) have promised a procedure with an outstanding sensitivity for the detection of early stage bladder cancer. Summarized here is our clinical experience and data comprising 1012 fluorescence endoscopies. Methods: Two hours, 30 minutes before endoscopy, 1.5 g 5-ALA dissolved in 50 ml of 5.7% sodium monohydrogen phosphate was instilled in patients intravesically. Before AFE, all patients underwent white light endoscopy, and a bladder washing cytologic specimen was obtained. A special light source provided blue light (375 to 440 nm) for fluorescence excitation. Suspicious sites were identified by their red fluorescence contrasting against backscattered blue light when observed through the long pass filter (445 nm) integrated into the telescope eyepiece. Results: Two thousand four hundred seventy-five specimens were obtained (2.4 biopsies per AFE). In 552 AFEs (54.5%), neoplastic urothelial lesions were detected, in 34.2% only because of their positive fluorescence; 38.7% of these additionally detected neoplastic foci had poorly differentiated histologic features. Conclusions: AFE has proved to be a clinically feasible procedure with an outstanding detection rate for flat, urothelial, high-risk lesions.

(PDF emailed within 0-6 h: $19.90)

Accession: 010585027

Download citation: RISBibTeXText

PMID: 11306382

DOI: 10.1016/s0090-4295(00)01053-0



Related references

Fluorescence detection of flat transitional cell carcinoma after intravesical instillation of aminolevulinic acid. American Journal of Clinical Oncology 21(3): 223-225, 1998

Clinical evaluation of a method for detecting superficial surgical transitional cell carcinoma of the bladder by light-induced fluorescence of protoporphyrin IX following the topical application of 5-aminolevulinic acid: preliminary results. Lasers in Surgery and Medicine 20(4): 402-408, 1997

Seven years' experience with 5-aminolevulinic acid in detection of transitional cell carcinoma of the bladder. Urology 69(2): 260-264, 2007

Detection of squamous cell carcinomas and pre-cancerous lesions in the oral cavity by quantification of 5-aminolevulinic acid induced fluorescence endoscopic images. Lasers in Surgery and Medicine 31(3): 151-157, 2002

Detection of squamous cell carcinoma of the oral cavity by imaging 5-aminolevulinic acid-induced protoporphyrin IX fluorescence. Laryngoscope 110(1): 78-83, 2000

Endoscopic fluorescence diagnosis of esophageal carcinoma after sensitization with 5-aminolevulinic acid. Medizinische Klinik 96(3): 157-160, 2001

Fluorescence induced with 5-aminolevulinic acid for the endoscopic detection and follow-up of esophageal lesions. Gastrointestinal Endoscopy 54(5): 572-578, 2001

Endoscopic detection of urinary bladder cancer with 5-aminolevulinic acid induced fluorescence. Journal of Urology 157(4 SUPPL ): 158, 1997

Kidney-preserving tumor resection in renal cell carcinoma with fluorescence photodetection by 5-aminolevulinic acid Preclinical and preliminary clinical results. Journal of Urology 163(4 Suppl ): 6, April, 2000

Endoscopic detection of urinary bladder cancer with 5-aminolevulinic acid based fluorescence endoscopy. Journal of Urology 161(4 SUPPL ): 170, April, 1999

Fluorescence endoscopic diagnosis for gastric cancers area after aminolevulinic acid treatment with a simultaneous endoscopic fluorescence analyzing system. Gastroenterology 122(4 Suppl 1): A-339, April, 2002

Endoscopic fluorescence detection of intraepithelial neoplasia in Barrett's esophagus after oral administration of aminolevulinic acid. Endoscopy 35(8): 663-668, 2003

Detection of neoplasms in the oral cavity by digitized endoscopic imaging of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence. International Journal of Oncology 21(4): 763-768, 2002

Endoscopic fluorescence diagnosis and laser treatment of transitional cell carcinoma of the bladder. Seminars in Urologic Oncology 18(4): 264-272, 2000