+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Endothelium-dependent relaxation in response to low concentrations of bradykinin is enhanced by phosphoramidon, bosentan and BQ-123 in bovine coronary arteries in vitro



Endothelium-dependent relaxation in response to low concentrations of bradykinin is enhanced by phosphoramidon, bosentan and BQ-123 in bovine coronary arteries in vitro



Japanese Journal of Pharmacology 86(2): 262-264



An endothelin (ET)-converting enzyme inhibitor phosphoramidon (10 microM), an ET(AB)-receptor antagonist bosentan (10 microM) and an ET(A)-receptor antagonist BQ-123 (1 microM) potentiated endothelium-dependent relaxation of bovine coronary arteries in response to bradykinin (BK) at femtomolar to picomolar concentrations, but not at nanomolar concentrations. BQ-788 (3 microM), an ET(B)-receptor antagonist, showed no significant effects on fM-nM BK-induced relaxation. These results suggest that the endothelium-dependent relaxation of isolated bovine coronary arteries induced by very low concentrations of BK is partly regulated by a complex mechanism involving the ET(A)-receptor antagonism.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010586743

Download citation: RISBibTeXText

PMID: 11459133

DOI: 10.1254/jjp.86.262


Related references

Potentiation by phosphoramidon of endothelium-dependent relaxation induced by bradykinin in isolated bovine coronary artery. Japanese Journal of Pharmacology 73(Suppl. 1): 166P, 1997

Cholinergic agonists and bradykinin produce endothelium dependent relaxation of bovine coronary arteries. FASEB Journal 5(5): A1420, 1991

Bradykinin-induced endothelium-dependent biphasic relaxation of bovine coronary artery in vitro. Japanese Journal of Pharmacology 67(Suppl. 1): 117P, 1995

Endothelium-dependent relaxation to the B1 kinin receptor agonist des-Arg9-bradykinin in human coronary arteries. British Journal of Pharmacology 116(8): 3083-3085, 1995

Femtomolar bradykinin-induced relaxation of isolated bovine coronary arteries, mediated by endothelium-derived nitric oxide. Journal Of Veterinary Pharmacology & Therapeutics. 21(4): 304-308,., 1998

Evidence that mechanisms dependent and independent of nitric oxide mediate endothelium-dependent relaxation to bradykinin in human small resistance-like coronary arteries. British Journal Of Pharmacology. 120(5): 757-762, 1997

Low level hyperlipidemia impairs endothelium-dependent relaxation of porcine coronary arteries by two mechanisms. Functional change in endothelium and impairment of endothelium-dependent relaxation by two mediators. Atherosclerosis 87(1): 23-38, 1991

Endothelium-dependent relaxation and hyperpolarization evoked by bradykinin in canine coronary arteries: Enhancement by exercise-training. British Journal of Pharmacology 117(3): 413-418, 1996

17Beta-estradiol acutely improves endothelium-dependent relaxation to bradykinin in isolated human coronary arteries. European Journal of Pharmacology 362(1): 73-76, 1998

Endothelium dependent relaxation of bovine coronary arteries by pgd 2. Naunyn-Schmiedeberg's Archives of Pharmacology 341(Suppl.): R36, 1990

Ace inhibitors potentiate endothelium dependent relaxations to threshold concentrations of bradykinin in coronary arteries. Journal of the American College of Cardiology 19(3 Suppl. A): 190A, 1992

Previous exposure to bradykinin unmasks an endothelium-dependent relaxation to the converting enzyme inhibitor trandolaprilat in isolated canine coronary arteries. Journal of Pharmacology and Experimental Therapeutics 272(2): 885-891, 1995

Bradykinin-Induced, N-Nitro-L-Arginine-Insensitive Endothelium-Dependent Relaxation of Porcine Coronary Arteries Is Not Mediated by Bioassayable Relaxing Substances. Journal of Cardiovascular Pharmacology 20: S101-S104, 1992

Bradykinin-induced, N omega-nitro-L-arginine-insensitive endothelium-dependent relaxation of porcine coronary arteries is not mediated by bioassayable relaxing substances. Journal of Cardiovascular Pharmacology 20(Suppl. 12): S101-S104, 1992

Endothelium dependent relaxation of isolated bovine retinal small arteries in vitro. Investigative Ophthalmology & Visual Science 31(4 ABSTR ISSUE): 170, 1990