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Epidermal and dermal distribution after topical application of liposome podophyllotoxin suspension in rats


Epidermal and dermal distribution after topical application of liposome podophyllotoxin suspension in rats



Zhonghua Pifuke Zazhi 36(6): 329-331



Objective To study the distribution pattern of liposome podophyllotoxin (LP) in rat skin. Methods The rats were divided into two groups: 0.5% liposome podophyllotoxin suspension was applied to LP group, 0.5% podophyllotoxin tincture was applied to control group. The skin specimens were obtained 1,2,4,6,12 and 24 h after drug application, the amount of fluorescent stain was observed under confocal laser scanning microscope and converted to the values of area under the curve (AUC). Results The epidermal AUC of fluorescent amount in LP group was 1.5-fold than that in control group, dermal AUC was 2.3-fold higher. The unit area fluorescent amount in both epidermis and dermis was highest 2 hours after topical medication in control group (1 585.52/mum2 and 2 005.66mum2), and quickly reduced after 4 hours. But the epidermal and dermal unit area fluorescent amount in LP group was rather low in 4 hours after topical medication, and gradually increased after 6 hours, and peaked after 12 hours (750.28/mum2 and 1 073.08/mum2). Conclusion Liposome preparation of podophyllotoxin can be slowly released and lasts longer in the skin.

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