+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Epstein-Barr virus infection of the colon with inflammatory bowel disease



Epstein-Barr virus infection of the colon with inflammatory bowel disease



American Journal of Gastroenterology 94(6): 1582-1586



OBJECTIVE: Epstein-Barr virus (EBV)-infected cells can evoke severe host immune responses, as shown in infectious mononucleosis and EBV-associated gastric carcinoma. To investigate the possible pathological role of EBV in inflammatory bowel disease (IBD), we tested for the presence of EBV in the colon in IBD patients. METHODS: Surgically resected colonic specimens of 11 patients with Crohn's disease, five patients with ulcerative colitis, nine noninflammatory controls (disease-free area of the colorectal carcinoma), and 10 appendicitis cases were tested using highly sensitive in situ hybridization for EBV-encoded small RNA1 (EBER-1). RESULTS: EBER-1 was detected in 63.6% of Crohn's disease cases and 60% of ulcerative colitis cases, but not at all in noninflammatory controls and appendicitis cases. EBER-1-positive cells were very rare in the noninflammatory areas of colonic specimens from IBD patients. EBER-1-positive cells were nonepithelial cells (mainly B lymphocytes and a few histiocyte-shaped cells) located in erosive or ulcerative areas of the colonic specimens. CONCLUSION: The limited presence of EBV-infected cells in the diseased areas of IBD colonic specimens indicated that EBV infection may be related to such diseases.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010600323

Download citation: RISBibTeXText

PMID: 10364028

DOI: 10.1016/s0002-9270(99)00204-x


Related references

Inflammatory bowel disease exacerbation associated with Epstein-Barr virus infection. Diseases of the Colon and Rectum 56(3): 322-327, 2013

Epstein-Barr virus infection in colorectal neoplasms associated with inflammatory bowel disease: detection of the virus in lymphomas but not in adenocarcinomas. Journal of Pathology 201(2): 312-318, 2003

Prevalence of cytomegalovirus and Epstein Barr virus in inflamed colon tissue of patients with mild to moderate inflammatory bowel disease - Preliminary results. American Journal of Gastroenterology 102(Suppl. 2): S488, 2007

Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease: need for mucosal viral load measurement. World Journal of Gastroenterology 21(6): 1915-1926, 2015

Severe chronic active Epstein-Barr virus infection mimicking steroid-dependent inflammatory bowel disease. Pediatric Infectious Disease Journal 24(3): 261-264, 2005

Epstein-Barr virus infection and expression of the interleukin-12 family member EBV-Induced gene 3 in chronic inflammatory bowel disease. Journal of Medical Virology 73(3): 432-438, 2004

Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease. Journal of Medical Virology 73(3): 432-438, 2004

Epstein-Barr virus and inflammatory bowel disease. Experientia 27(12): 1474-1475, 1971

Epstein-Barr virus related lymphoma in inflammatory bowel disease. Acta Gastro-Enterologica Belgica 71(1): 33-35, 2008

Prevalence of Epstein-Barr virus in patients with inflammatory bowel disease. 2007

Epstein-Barr virus in inflammatory bowel disease-correlation with different therapeutic regimens. Inflammatory Bowel Diseases 19(8): 1710-1716, 2013

Epstein-Barr virus-related lymphomas in patients with inflammatory bowel disease. Nederlands Tijdschrift Voor Geneeskunde 149(33): 1859-1863, 2005

Infection of mouse lymphocytes by epstein barr virus 2. stimulation of cellular dna synthesis by epstein barr virus in the absence of epstein barr virus determined nuclear antigen induction and cell transformation. Virology 133(1): 211-215, 1984

Establishment of epstein barr virus nuclear antigen expressing cell lines by infection of epstein barr virus genome negative human lymphoma cells with different epstein barr virus strains. International Journal Of Cancer: 161-166, 1976