+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Etiology of sporadic acute viral hepatitis in Taiwan: The role of hepatitis C virus, hepatitis E virus and GB virus-C/hepatitis G virus in an endemic area of hepatitis A and B



Etiology of sporadic acute viral hepatitis in Taiwan: The role of hepatitis C virus, hepatitis E virus and GB virus-C/hepatitis G virus in an endemic area of hepatitis A and B



Journal of Medical Virology 58(2): 154-159



The etiology of sporadic acute hepatitis was studied in 334 consecutive patients from Taiwan (237 men and 97 women, aged 16-81 years), with emphasis on the role of hepatitis C virus (HCV), hepatitis E virus (HEV), and GB virus-C/hepatitis G virus (GBV-C/HGV) in acute non-A, non-B (NANB) hepatitis and in HBsAg carriers with superimposed acute hepatitis. According to the conventional diagnostic criteria, there were 12 cases (3.6%) of acute hepatitis A, 17 cases (5.1%) of acute hepatitis B, 128 cases (38.3%) of acute NANB hepatitis, and 177 cases (53.0%) of acute hepatitis in HBsAg carriers (those who were HBsAg positive but IgM anti-HBc negative). Among 128 cases of acute NANB hepatitis, 70 (54.7%) had acute hepatitis C (HCV RNA positive), 5 (3.9%) had acute hepatitis E (IgM anti-HEV positive), and the other 53 (41.4%) were presumably acute hepatitis non-A-E. The prevalence of acute hepatitis A, B, E, and non-A-E showed no significant sex difference, whereas acute hepatitis C was significantly more prevalent in females. The prevalence of acute hepatitis A and B decreased and that of acute hepatitis C increased significantly with increasing age. In contrast, acute hepatitis E and non-A-E showed no significant age predominance. Of 177 HBsAg carriers with acute hepatitis, 64 (36.1%) demonstrated non-B hepatotropic virus superinfection, with HCV being the most common (60.9%), followed by hepatitis D, E, and A viruses, and the other 55 (31.1%) and 58 (32.8%) were presumed to have acute exacerbation of chronic hepatitis B or superimposed acute hepatitis non-A-E, respectively. Serum GBV-C/HGV RNA was detected in 3-4% of acute hepatitis non-A-E cases, suggesting its limited role in these cases.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010610518

Download citation: RISBibTeXText

PMID: 10335863

DOI: 10.1002/(sici)1096-9071(199906)58:2<154::aid-jmv9>3.0.co;2-e


Related references

Prevalence of hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E virus as causes of acute viral hepatitis in North India: a hospital based study. Indian Journal of Medical Microbiology 31(3): 261-265, 2014

Serological profile of sporadic acute viral hepatitis in an area of hyper-endemic hepatitis B virus infection. Saudi Journal of Gastroenterology 7(3): 95, 2001

Hepatitis delta virus and GBV-C infection in two neighboring hepatitis B virus and hepatitis C virus-endemic villages in Taiwan. Chang Gung Medical Journal 33(2): 137-144, 2010

The role of hepatitis C virus in fulminant viral hepatitis in an area with endemic hepatitis A and B. Gastroenterology 107(1): 189-195, 1994

Role of hepatitis E virus in sporadic cases of acute and fulminant hepatitis in an endemic area (Chad). American Journal of Tropical Medicine and Hygiene 58(3): 330-334, 1998

Acute hepatitis A and acquired immunity to hepatitis A virus in hepatitis B virus (HBV) carriers and in HBV- or hepatitis C virus-related chronic liver diseases in Thailand. Journal of Viral Hepatitis 7(Suppl. 1): 11-12, 2000

Prevalence of hepatitis G virus and hepatitis C virus infection in hepatitis B virus endemic area, Kamchatka, Russia. Hepatology 26(4 Part 2): 467A, 1997

Hepatitis B and hepatitis A markers in 33 cases of acute hepatitis B surface antigen-negative, hepatitis A virus antibody-positive viral hepatitis. Importance of immune complexes. Minerva Medica 73(18): 1169-1172, 1982

Predominant etiologic association of hepatitis C virus with hepatocellular carcinoma compared with hepatitis B virus in elderly patients in a hepatitis B-endemic area. Cancer 72(9): 2564-2567, 1993

High prevalence of hepatitis delta virus among patients with chronic hepatitis B virus infection and HIV-1 in an intermediate hepatitis B virus endemic region. Journal of the International Association of Providers of Aids Care 13(1): 85-90, 2014

Aflatoxin exposure and hepatitis C virus in advanced liver disease in a hepatitis C virus-endemic area in Taiwan. American Journal of Tropical Medicine and Hygiene 77(4): 747-752, 2007

Noncirrhotic hepatocellular carcinoma: etiology and occult hepatitis B virus infection in a hepatitis B virus-endemic area. Therapeutic Advances in Gastroenterology 10(7): 529-536, 2017

The high rate of antibodies to hepatitis E virus in young, intravenous drug-abusers with acute hepatitis B-virus infection in a Swedish community: a study of hepatitis markers in individuals with intravenously or sexually acquired hepatitis B-virus infection. Scandinavian Journal of Infectious Diseases 30(4): 429-430, 1998

Interferon-Free Regimens in Hepatitis B Surface Antigen/Anti-Hepatitis C Virus Positive Patients: The Need to Control Hepatitis B Virus Replication to Avoid Hepatitis B Virus Reactivation. Clinical Gastroenterology and Hepatology 15(11): 1800-1802, 2017

Correlation of hepatitis b virus hepatitis d virus and human immunodeficiency virus type i infection markers in hepatitis b surface antigen positive haemophiliacs and patients without haemophilia with clinical and histopathological outcome of hepatitis. European Journal of Pediatrics 151(2): 90-94, 1992