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Evidence for the existence of a common ancestor of scorpion toxins affecting ion channels


Evidence for the existence of a common ancestor of scorpion toxins affecting ion channels



Journal of Biochemical and Molecular Toxicology 17(4): 235-238



ISSN/ISBN: 1095-6670

PMID: 12898647

DOI: 10.1002/jbt.10083

All scorpion toxins from different 30 species are simply reviewed. A new classification system of scorpion toxins is first proposed: scorpion toxins are classified into three families (long-chain scorpion toxins with 4 disulfide bridges, short-chain scorpion toxins with 3 disulfide bridges, and intermediate-type scorpion toxins with 3 or 4 disulfide bridges). Intermediate-type scorpion toxins provide a strong proof for the conclusion that channel toxins from scorpion venoms evolve from a common ancestor. Common organization of precursor nucleotides and genomic sequence, similar 3-dimensional structure, and the existence of intermediate type scorpion toxins and functionally intercrossing scorpion toxins show that all scorpion toxins affecting ion channels evolve from the common ancestor, which produce millions of scorpion toxins with function-diversity.

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Accession: 010623469

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