+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Evidence for the existence of a common ancestor of scorpion toxins affecting ion channels

Evidence for the existence of a common ancestor of scorpion toxins affecting ion channels

Journal of Biochemical and Molecular Toxicology 17(4): 235-238

ISSN/ISBN: 1095-6670

PMID: 12898647

DOI: 10.1002/jbt.10083

All scorpion toxins from different 30 species are simply reviewed. A new classification system of scorpion toxins is first proposed: scorpion toxins are classified into three families (long-chain scorpion toxins with 4 disulfide bridges, short-chain scorpion toxins with 3 disulfide bridges, and intermediate-type scorpion toxins with 3 or 4 disulfide bridges). Intermediate-type scorpion toxins provide a strong proof for the conclusion that channel toxins from scorpion venoms evolve from a common ancestor. Common organization of precursor nucleotides and genomic sequence, similar 3-dimensional structure, and the existence of intermediate type scorpion toxins and functionally intercrossing scorpion toxins show that all scorpion toxins affecting ion channels evolve from the common ancestor, which produce millions of scorpion toxins with function-diversity.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 010623469

Download citation: RISBibTeXText

Related references

Dynamic diversification from a putative common ancestor of scorpion toxins affecting sodium, potassium, and chloride channels. Journal of molecular evolution 48(2): 187-196, 1999

A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels. Biochemical Pharmacology 76(6): 805-815, 2008

Dissection of the functional surface of an anti-insect excitatory toxin illuminates a putative "hot spot" common to all scorpion beta-toxins affecting Na+ channels. Journal of Biological Chemistry 279(9): 8206-8211, 2004

Two non-coding transcripts of toxins from the scorpion Buthus martensii Karsch: evidence for the existence of NMD in scorpion venom gland cells. Chinese Science Bulletin 47(1): 47-51, 2002

Genomic organization of scorpion toxins active on K+ channels and evidence for a new class of toxins. Toxicon 36(9): 1244, 1998

Australian funnel-web spider toxins and alpha-scorpion toxins share a common binding site on cockroach and rat voltage-gated sodium channels. Toxicon 36(9): 1273-1274, 1998

Structure and function of scorpion toxins affecting K+-channels. Perspectives in Drug Discovery and Design 15-16: 15-40, 1999

Functional anatomy of scorpion toxins affecting sodium channels. Journal of Toxicology Toxin Reviews 17(2): 131-159, 1998

Evolutionary diversification of Mesobuthus α-scorpion toxins affecting sodium channels. Molecular and Cellular Proteomics: Mcp 11(1): M111.012054, 2012

Molecular divergence of two orthologous scorpion toxins affecting potassium channels. Comparative Biochemistry and Physiology. Part A Molecular and Integrative Physiology 159(3): 313-321, 2011

Evidence for a new class of scorpion toxins active against K+ channels. Febs Letters 431(3): 375-380, 1998

Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins. Journal of Biological Chemistry 279(53): 55690-55696, 2004

Refined structure of BeM9 reveals arginine hand, an overlooked structural motif in scorpion toxins affecting sodium channels. Proteins 86(10): 1117-1122, 2018

Common features in the functional surface of scorpion beta-toxins and elements that confer specificity for insect and mammalian voltage-gated sodium channels. Journal of Biological Chemistry 280(6): 5045-5053, 2005

Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels. Journal of Biological Chemistry 271(14): 8034-8045, 1996