Experimental study on the relationship between serum creatinine, blood urea nitrogen and blood perfusion of renal cortex in acute renal failure using intravenous contrast ultrasound

Yang-Weixiao; Gao-Yunhua; Zhu-Xiansheng

Zhongguo Chaosheng Yixue Zazhi 18(10): 725-728

2002


Accession: 010633437

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Abstract
Objective: To explore the relationship between the serum creatinine (SCr), blood urea nitrogen (BUN) levels and the blood perfusion of renal cortex in acute renal failure (ARF). Methods: The model of ARF was established by the intramuscular injection of 50% glycerol (12-15ml/kg) into the hind limbs of 18 rabbits. The levels of SCr and BUN were measured on the day before injection (T0) and the days 1, 2, 3, 5cntdotcntdotcntdot11, 13 after injection (T1, T2, T3, T5cntdotcntdotcntdotT11, T13 while ultrasonic examination was performed by intravenous contrast ultrasound and acoustic densitometry (AD) technique to acquire some perfusion parameters of renal cortex such as peak intensity (PI) and the area under the curve (AUC). Then, the correlation of examination results was analyzed by statistic mehtods. Results: The PI and ACU of renal cortex after injecting contrast agent and SCr, BUN levels have changed greatly at T1 compared to T0. The PI, AUC were decreased to their lowest values at T3 and then began to be increased and reached to thier normal levels at T9 finally. The SCr and BUN were increased to thier highest levels at T5 and remained at this high level to T9 and then began to be decreased slowly. From T0 to T13, the relative coefficients of PI and AUC of renal cortex after injecting contrast agent to SCr were 0.66 and 0.58 respectively. The relative coefficients of PI and AUC of renal cortex after injecting contrast agent to BUN were 0.64 and 0.61 respectively. Conclusions: During ARF stage, PI, AUC, SCr, and BUN all changed earlier, but the PI, AUC maintained abnormal shortly and recovered rapidly. The SCr and BUN remained at abnormal levels for a longer time and recovered slowly. From t0 to T13, the PI and AUC values of renal cortex did not correlate to SCr and BUN levels.