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Expression de la proteine p21WAF1/CIP1 dans les cancers colorectaux: Etude de sa relation avec les mutations du gene p53 et l'expression de la proteine p53 et de l'antigene Ki67

Expression de la proteine p21WAF1/CIP1 dans les cancers colorectaux: Etude de sa relation avec les mutations du gene p53 et l'expression de la proteine p53 et de l'antigene Ki67

Pathologie Biologie 49(2): 115-123

Mutations of the p53 gene are the most common genetic alteration in malignant human tumors. A cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is thought to be an important mediator of p53-induced cell cycle arrest. Although numerous studies have reported p53 expression and mutation in colorectal cancer few of them have correlated p53 expression with that of its downstream effector p21 and with the proliferation index as measured by expression of the Ki67 nuclear antigen.

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