+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Expression of ErbB receptors during pancreatic islet development and regrowth

Expression of ErbB receptors during pancreatic islet development and regrowth

Journal of Endocrinology 165(1): 67-77

We have characterized expression of the ErbB receptor family and one of its ligands, heregulin, in an effort to identify molecules associated with pancreatic development and regeneration. In addition to studying expression during fetal pancreatic development, we have also studied expression during pancreatic regeneration in the interferon-gamma (IFNgamma)-transgenic mouse, which exhibits significant duct cell proliferation and new islet formation. These studies demonstrate significant expression of the ErbB2, ErbB3, and ErbB4 receptors, in addition to heregulin isoforms, in the developing murine fetal pancreas. We also report significant ductal expression of these proteins during IFNgamma-mediated pancreatic regeneration. This striking expression was absent in 1-week-old neonates, but was clearly visible in pups by 5 weeks of age. These data therefore indicate that ErbB receptor and ligand expression decline by birth in both the IFNbeta-transgenic and non-transgenic mice, and that expression resumes early in postnatal life in the IFNbeta-transgenic mice. The expression of ErbB receptor family members at sites of islet development and regrowth suggests that these molecules might be relevant to these processes.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 010637662

Download citation: RISBibTeXText

PMID: 10750037

DOI: 10.1677/joe.0.1650067

Related references

Simultaneous expression of Cathepsins B and K in pulmonary adenocarcinomas and squamous cell carcinomas predicts poor recurrence-free and overall survival. Lung Cancer 64(1): 79-85, 2009

Differential expression of NADPH-diaphorase in the dorsal root ganglia and sympathetic ganglia in streptozotocin-induced diabetic rats. Society for Neuroscience Abstracts 25(1-2): 410, 1999

Pancreatic islet cell carcinoma with hypercalcemia: complete remission 5 years after surgical excision and chemotherapy. American Journal of Gastroenterology 86(5): 635-638, 1991

GPR119 as a fat sensor. Trends in Pharmacological Sciences 33(7): 374-381, 2012

Expression of pancreatic alpha-amylase protein and messenger RNA in hilar primitive bile ducts and hepatocytes during human fetal liver organogenesis An immunohistochemical and in situ hybridization study. Liver. 18(5): 313-319,., 1998

Expression and role of interleukin-2 receptor beta chain on CD4-negative CD8 negative T cell receptor alpha-beta-positive cells. European Journal of Immunology 22(11): 2929-2936, 1992

K-ras oncogene mutations in sporadic colorectal cancer in the Netherlands Cohort Study. Carcinogenesis 24(4): 703-710, 2003

EGFR dependent expression of STAT3 (but not STAT1) in breast cancer. International Journal of Oncology 19(6): 1155-1160, 2001

Reduced thymic Aire expression and abnormal NF-kappa B2 signaling in a model of systemic autoimmunity. Journal of Immunology 182(5): 2690-2699, 2009

Changes in the excitability of hindlimb motoneurons during muscular atonia induced by stimulating the pedunculopontine tegmental nucleus in cats. Neuroscience 124(2): 467-480, 2004

Eragrostis curvula (Schrad.) Nees. complex pastures in southern New South Wales, Australia: a comparison with Medicago sativa L. and Phalaris aquatica L. pastures under rotational grazing. Australian Journal of Experimental Agriculture 45(4): 401-420, 2005

Regulation of epstein barr virus transformation of b cells producing cell surface reactive antibodies. Clinical Research 37(2): 417A, 1989

Expression of receptors for IgA in hairy-cell and other B-cell leukaemias. British Journal of Haematology 49(4): 643-647, 1981

Co-expression of eotaxin-2 and IL-5 in double transgenic mice leads to eosinophil degranulation and the development of pulmonary pathologies. Journal of Allergy and Clinical Immunology 113(2 Suppl.): S188, 2004