+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Glutamatergic and GABAergic regulation of neural responses in inferior colliculus to amplitude-modulated sounds



Glutamatergic and GABAergic regulation of neural responses in inferior colliculus to amplitude-modulated sounds



Journal of Neurophysiology 90(1): 477-490



Recordings were made from single neurons in the rat inferior colliculus in response to sinusoidally amplitude-modulated sounds (10-s duration) presented to the contralateral ear. Neural responses were determined for different rates of modulation (0.5 Hz to 1 kHz) at a depth of 100%, and modulation transfer functions were generated based on firing rate (MTFFR) and vector strength (MTFVS). The effects of AMPA, NMDA, and GABAA receptor antagonists were examined by releasing drugs iontophoretically through a multibarrel pipette attached to a single-barrel recording pipette. Both the AMPA receptor antagonist, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium (NBQX), and the NMDA receptor antagonist, (+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) resulted in a decrease in firing rate, and the GABAA receptor antagonist, bicuculline, produced an increase in the firing rate in most of the cells examined. In some cases, the shape of the MTFFR was modified slightly by receptor antagonists, but in most cases, the peak firing rate that determined a neuron's best modulation frequency remained the same. Also there were no changes during delivery of either excitatory or inhibitory antagonists in the maximum response synchrony at the peak of the MTFVS although some changes were noticed at off-peak modulation rates particularly with the AMPA receptor antagonist, NBQX.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010720018

Download citation: RISBibTeXText

PMID: 12660357

DOI: 10.1152/jn.01084.2002


Related references

Responses to amplitude modulated sounds in the inferior colliculus of the mustached bat pteronotus parnellii. Society for Neuroscience Abstracts 12(2): 1271, 1986

Responses of specialized neurons of the colliculus inferior of rats to amplitude modulated sounds. Zhurnal Evolyutsionnoi Biokhimii I Fiziologii: 207-217, 1969

GABAergic inputs shape responses to amplitude modulated stimuli in the inferior colliculus. Hearing Research e; 168(1-2): 163-173, 2002

Stimulus properties influencing the responses of inferior colliculus neurons to amplitude-modulated sounds. Hearing Research 27(2): 129-143, 1987

Responses of auditory neurons in the inferior colliculus to amplitude modulated sounds with changing intensity level. Neirofiziologiya 5(4): 355-366, 1973

A computational model of inferior colliculus responses to amplitude modulated sounds in young and aged rats. Frontiers in Neural Circuits 6: 77, 2012

Ontogenetic development of responses to amplitude-modulated sounds by neurons in the inferior colliculus of the Mongolian gerbil. Elsner, N, Menzel, R Learning and memory 152, 1995

Effects of changes in carrier frequency and modulation rate on unit responses in the inferior colliculus to amplitude modulated sounds. Neurophysiology 4(1): 8-16, 1972, 1973

Responses of auditory neurons in the inferior colliculus to amplitude modulated sounds with changing carrier frequency and modulation rate. Neirofiziologiya 4(1): 12-22, 1972

Temporal and spatial patterns of neuronal responses to amplitude modulated and harmonic sounds in frequency band laminae in the inferior colliculus of cat. Society for Neuroscience Abstracts 16(1): 719, 1990

A neural mechanism of phase-locked responses to sinusoidally amplitude-modulated signals in the inferior colliculus. Bio Systems 134: 24-36, 2015

The influence of noise on the selectivity of neurons in the inferior colliculus of the rat for amplitude modulated sounds. Society for Neuroscience Abstracts 10(1): 395, 1984

Neural coding of amplitude modulated tones in the inferior colliculus. Society for Neuroscience Abstracts 23(1-2): 733, 1997

Neural coding of amplitude modulated tones in the inferior colliculus of kitten. Japanese Journal of Physiology 40(Suppl.): S187, 1990

Properties of responses to amplitude modulated tones in the inferior colliculus. Society for Neuroscience Abstracts 25(1-2): 396, 1999