+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Growth hormone secretion in children and adolescents at high risk for major depressive disorder

Growth hormone secretion in children and adolescents at high risk for major depressive disorder

Archives of General Psychiatry 57(9): 867-872

Background: Decreased growth hormone (GH) response to pharmacologic stimulation has been found in children and adolescents during an episode of major depressive disorder and after recovery. In this study, we sought to determine whether GH secretion is similarly altered in children and adolescents who had never experienced depression but were at high risk of developing depression. Methods: Subjects were 8 through 16 years of age and selected for high- and low-risk status according to familial loading for mood disorders. Sixty-four high-risk and 55 low-risk healthy subjects participated in the study, which assessed the following GH measures: (1) GH before growth hormone-releasing hormone (GHRH) infusion, every 15 minutes for 30 minutes; (2) GH response after intravenous infusion of GHRH (0.1 mug/kg), every 15 minutes for 90 minutes; and (3) nocturnal GH every 20 minutes from 9 PM until morning awakening. Results: After stimulation with GHRH, the high-risk subjects secreted significantly less GH compared with the low-risk healthy controls (effect sizes for mean and peak GH, 0.52 (P = .007) and 0.40 (P = .04), respectively). In contrast, there were no between-group differences in the pre-GHRH and nocturnal GH secretion levels. Exposure to recent stressors was not associated with GH secretion. Conclusions: Taken together with previous evidence of decreased GH after GHRH infusion in acutely depressed and recovered children, these results indicate that the decreased GH response found in high-risk subjects may represent a trait marker for depression in children and adolescents.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 010726983

Download citation: RISBibTeXText

PMID: 10986550

DOI: 10.1001/archpsyc.57.9.867

Related references

Antecedents of New-Onset Major Depressive Disorder in Children and Adolescents at High Familial Risk. JAMA Psychiatry (): -, 2016

Risk factors for incident major depressive disorder in children and adolescents with attention-deficit/hyperactivity disorder. European Child & Adolescent Psychiatry 24(1): 65-73, 2015

Neuroendocrine regulation of growth hormone secretion in major depressive disorder. Pharmacopsychiatry 21(6): 440-442, 1988

Family functioning in adolescents at high and low risk for major depressive disorder. European Child & Adolescent Psychiatry 10(3): 170-179, 2001

Growth hormone dysregulation in children with major depressive disorder. Journal of the American Academy of Child and Adolescent Psychiatry 29(2): 295-301, 1990

Clonidine-induced growth hormone secretion in elderly patients with senile dementia of the Alzheimer type and major depressive disorder. Psychiatry Research 27(3): 277-286, 1989

Internalized HIV stigma, bullying, major depressive disorder, and high-risk suicidality among HIV-positive adolescents in rural Uganda. Global Mental Health 5: E22-E22, 2018

Is growth hormone deficiency associated with anxiety disorder and depressive symptoms in children and adolescents?: A case-control study. Growth Hormone & Igf Research 41: 23-27, 2018

Clinical characteristics of depressive symptoms in children and adolescents with major depressive disorder. Journal of Clinical Psychiatry 65(12): 1654-9; Quiz 1760-1, 2005

Fluoxetine decreased depressive symptoms in children and adolescents with non-psychotic major depressive disorder. Evidence-Based Mental Health 1(2): 49-49, 1998

Escalation to Major Depressive Disorder among adolescents with subthreshold depressive symptoms: evidence of distinct subgroups at risk. Journal of Affective Disorders 158(): 133-138, 2015

Cortisol secretion in adolescents with major depressive disorder. Acta Psychiatrica Scandinavica 80(1): 18-26, 1989

Add-on high frequency deep transcranial magnetic stimulation (dTMS) to bilateral prefrontal cortex in depressive episodes of patients with Major Depressive Disorder, Bipolar Disorder I, and Major Depressive with Alcohol Use Disorders. Neuroscience Letters, 2018

Neuroendocrine response to 5-hydroxy-L-tryptophan in prepubertal children at high risk of major depressive disorder. Archives of General Psychiatry 54(12): 1113-1119, 1997

Growth hormone secretion in prepubertal children with major depression. II. Sleep-related plasma concentrations during a depressive episode. Archives of General Psychiatry 41(5): 463-466, 1984