+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Healthy twin delivery after day 7 blastocyst transfer coupled with assisted hatching



Healthy twin delivery after day 7 blastocyst transfer coupled with assisted hatching



Fertility & Sterility 77(3): 615-617



Objective: To report a normal twin delivery after transfer of two fresh day 7 blastocysts. Design: Case report. Setting: Private infertility clinic. Patient(s): A 35-year-old woman with a 6-year history of primary infertility with significant pelvic adhesions. Intervention(s): Review of individual IVF-ET therapy cycle. Main Outcome Measure(s): Full-term delivery after day 7 blastocyst transfer. Result(s): During the patient's first IVF-ET cycle, the decision was made to undertake blastocyst transfer after extended culture. No blastocysts had formed until late on day 6, by which time the patient had been hospitalized with a renal stone. Subsequently, on day 7, the patient was asymptomatic and presented for embryo transfer, and after assisted hatching, two expanded blastocysts were transferred to her uterus under ultrasound guidance. After confirmation of implantation of a viable twin, pregnancy was uneventful with no obstetrical complications, and a dizygotic twin was delivered vaginally at 38 weeks of gestation. Conclusion(s): Few reports have been made regarding viability of more slowly developing blastocysts; however, this case indicates that blastocysts that did not fully expand until day 7 of extended in vitro culture are still able to implant after superovulation and IVF-ET therapy. Assisted hatching of these embryos may have been beneficial in achieving this successful outcome by hastening the blastocyst hatching, allowing more rapid contact with the endometrium.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010737324

Download citation: RISBibTeXText

PMID: 11872221

DOI: 10.1016/s0015-0282(01)03199-5


Related references

Comparison of blastocyst transfer to day 3 transfer with assisted hatching in the older patient. Fertility & Sterility 78(6): 1244-1247, 2002

Transfer of spontaneously hatching or hatched blastocyst yields better pregnancy rates than expanded blastocyst transfer. Journal of Human Reproductive Sciences 6(3): 183-188, 2013

Effect of the site of assisted hatching on vitrified-warmed blastocyst transfer cycles: a prospective randomized study. Journal of Assisted Reproduction and Genetics 30(5): 691-697, 2013

Zona-free versus laser zona-assisted hatching blastocyst transfer: a comparison of outcomes. Fertility and Sterility 91(5): 1959-1962, 2009

Comparison of laser-assisted hatching and acidified Tyrode's hatching by evaluation of blastocyst development rates in sibling embryos: a prospective randomized trial. Fertility and Sterility 85(2): 487-491, 2006

Comparison between Cleavage Stage versus Blastocyst Stage Embryo Transfer in an Egyptian Cohort Undergoing in vitro Fertilization: A Possible Role for Laser Assisted Hatching. Clinical Medicine Insights. Reproductive Health 5: 41-48, 2011

Effect of the size of zona pellucida opening by laser assisted hatching on clinical outcome of frozen cleaved embryos that were cultured to blastocyst after thawing in women with multiple implantation failures of embryo transfer: a retrospective study. Journal of Assisted Reproduction and Genetics 25(4): 129-135, 2008

Atypical hatching of a cow blastocyst leading to separation of complete twin half blastocysts. Veterinary Record 112(13): 301-301, 1983

Case report Visualization of atypical hatching of a human blastocyst in vitro forming a monozygotic twin. Fertility & Sterility 80(Suppl 3): S253, 2003

Two-headed, two-necked conjoined twin calf with partial duplication of thoracoabdominal structures: role of blastocyst hatching. Anatomical Record 217(2): 196-202, 1987

Monozygotic twinning after in vitro fertilization/intracytoplasmic sperm injection treatment is not related to advanced maternal age, intracytoplasmic sperm injection, assisted hatching, or blastocyst transfer. Taiwanese Journal of Obstetrics and Gynecology 53(3): 324-329, 2014

Influence of serum and BSA on blastocyst development and hatching in IVF and nuclear transfer bovine embryos. Reproduction Fertility & Development 16(1-2): 200, 2004

Blastocyst development and birth after in-vitro maturation of human primary oocytes, intracytoplasmic sperm injection and assisted hatching. Human Reproduction 10(12): 3243-3247, 1995

The effect of long zona dissection using ICSI pipettes for mechanical assisted hatching in vitrified-thawed blastocyst transfers. Journal of Assisted Reproduction and Genetics 29(12): 1431-1434, 2012

Vaginal delivery of a healthy twin after early fetal abortion of the first twin with a pathologic karyotype. Zeitschrift für Geburtshilfe und Perinatologie 198(3): 106-107, 1994