+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hemodynamic and electrocardiographic effects of almotriptan in healthy volunteers



Hemodynamic and electrocardiographic effects of almotriptan in healthy volunteers



Journal of Cardiovascular Pharmacology 37(3): 280-289



We studied the possible cardiovascular effects of single oral doses of 12.5, 25, and 50 mg of almotriptan, a new triptan for treatment of migraine, in a randomized, double-blind, four-way crossover, placebo-controlled study in 24 healthy volunteers aged 18 to 35 years. Doses were given at 1-week intervals. Cardiovascular effects were assessed by frequent recording of blood pressure and heart rate, 12-lead electrocardiogram (ECG) (recorded at 25 mm/s paper speed and 1 cm/mV and at 50 mm/s and 2 cm/mV), and continuous ECG monitoring for 12 h after each dose. ECG variables, PR, QRS, QT interval, and QT dispersion, were measured. QT intervals were adjusted for heart rate using Bazett's formula. None of the doses of almotriptan differed significantly from placebo with respect to PR, QRS, or QTc intervals, QTc dispersion, heart rate, or continuous ECG monitoring. Almotriptan 12.5 mg did not differ significantly from placebo with respect to systolic or diastolic blood pressure, but almotriptan 25 and 50 mg raised systolic blood pressure by a mean of 2.78 and 4.17 mm Hg, and diastolic blood pressure by 3.77 and 6.11 mm Hg, respectively, during 0 to 4 h after dosing. Thus none of the doses of almotriptan affected the ECG, and the 12.5-mg dose (the expected therapeutic dose) had no hemodynamic effects. Almotriptan in doses of 25 and 50 mg caused a small, dose-related increase in systolic and diastolic blood pressure, as seen with other triptans.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010741414

Download citation: RISBibTeXText

PMID: 11243418

DOI: 10.1097/00005344-200103000-00006


Related references

Evaluation of electrocardiographic and hemodynamic effects of caffeine with acute dosing in healthy volunteers. PharmacoTherapy 21(4): 437-442, 2001

Hemodynamic and electrocardiographic effects of açaí berry in healthy volunteers: a randomized controlled trial. International Journal of Cardiology 174(2): 421-423, 2014

Systemic and regional hemodynamic electrocardiographic and biological effects of a new calcium antagonist elgodipine in healthy volunteers. Fundamental & Clinical Pharmacology 5(5): 421, 1991

Interaction between ketoconazole and almotriptan in healthy volunteers. Journal of Clinical Pharmacology 43(4): 423-427, 2003

Lack of interaction between propranolol and almotriptan in healthy volunteers. Neurology 54(7 Supp 3): A268-A269, 2000

Pharmacokinetic interaction between verapamil and almotriptan in healthy volunteers. Clinical Pharmacology and Therapeutics 67(5): 498-503, 2000

Pharmacokinetics and safety of oral almotriptan in healthy male volunteers. Biopharmaceutics and Drug Disposition 25(7): 303-311, 2004

Evaluation of the potential pharmacokinetic interaction between almotriptan and fluoxetine in healthy volunteers. Journal of Clinical Pharmacology 41(2): 217-223, 2001

Lack of pharmacokinetic interaction between the antimigraine compound, almotriptan, and propranolol in healthy volunteers. Cephalalgia 21(1): 61-65, 2001

Studies in healthy volunteers do not show any electrocardiographic effects with esomeprazole. Clinical Drug Investigation 20(6): 425-431, 2000

Absolute bioavailability, pharmacokinetics, and urinary excretion of the novel antimigraine agent almotriptan in healthy male volunteers. Journal of Clinical Pharmacology 42(12): 1303-1310, 2002

Intravenous conivaptan: effects on the QTc interval and other electrocardiographic parameters in healthy volunteers. Advances in Therapy 24(2): 310-318, 2007

Hemodynamic effects of labetalol in healthy volunteers. International Journal of Clinical Pharmacology Therapy and Toxicology 20(11): 517-519, 1982

Hemodynamic and electrocardiographic effects of magnesium sulfate in healthy dogs. Journal of Veterinary Internal Medicine 13(5): 485-490, 1999

Effects of atropine on autonomic indices based on electrocardiographic R-R intervals in healthy volunteers. Journal of Neurology Neurosurgery and Psychiatry 55(1): 31-35, 1992