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Hepatitis B virus of genotype C persistence after recovery from acute hepatitis B virus infection in Japan

Hepatitis B virus of genotype C persistence after recovery from acute hepatitis B virus infection in Japan

Hepatology Research 25(3): 244-253

Background/aims: this study aimed to determine the viremia status after clinical, biochemical and serological recovery from acute hepatitis B viral (HBV) infection. Methods: we detected serum HBV-DNA in 19 patients with acute hepatitis B during followed-up 6-43 months after onset, and analyzed HBV genotypes. Results: 13 (72%) of 19 patients had detectable HBV DNA at the point of 6 months after onset, and four (33%) of 12 patients had persisted viremia for more than 1 year although they were recovery with normalization of alanine transaminase (ALT), disappearance of hepatitis B surface antigen (HBsAg) and appearance of antibody against HBsAg (anti-HBs). Eighteen (95%) of 19 patients were infected with HBV genotype C, one (5%) with genotype B. Conclusions: these results suggest genotype C of HBV is the predominant genotype of acute hepatitis B in Nagasaki region in Japan. HBV can persist in the serum for more than one year after complete clinical and serological recovery from acute viral hepatitis.

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Accession: 010743598

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PMID: 12697245

DOI: 10.1016/s1386-6346(02)00276-0

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