+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hepatocyte growth factor/scatter factor promotes a switch from E- to N-cadherin in chick embryo epiblast cells



Hepatocyte growth factor/scatter factor promotes a switch from E- to N-cadherin in chick embryo epiblast cells



Experimental Cell Research 251(1): 3-15



Epiblast cells downregulate E-cadherin and upregulate N-cadherin as they ingress through the primitive streak and when placed in culture. The factors that promote the alteration in cadherin expression during gastrulation are unknown. The effects of hepatocyte growth factor/scatter factor (HGF/SF) on cadherin expression were tested in cultures of prestreak epiblast cells. HGF/SF decreased the expression of E-cadherin and increased the percentage of cells with N-cadherin and sarcomeric myosin. Cells with N-cadherin but not E-cadherin differentiated into skeletal muscle. HGF/SF also stimulated proliferation and the formation of cellular aggregates. Sensitivity to HGF/SF in vitro depended on the original position of cells within the epiblast. More cells from the lateral epiblast switched cadherins and proliferated in response to HGF/SF than medial epiblast cells. HGF/SF may affect gastrulation by altering cadherin expression, modulating cell adhesion, and stimulating proliferation within the epiblast.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010744590

Download citation: RISBibTeXText

PMID: 10438566

DOI: 10.1006/excr.1999.4577


Related references

The effects of hepatocyte growth factor/scatter factor on cadherin expression and muscle differentiation in cultures of epiblast cells. Molecular Biology of the Cell 8(SUPPL ): 330A, 1997

Hepatocyte growth factor/scatter factor is a neurotrophic survival factor for lumbar but not for other somatic motoneurons in the chick embryo. Journal of Neuroscience 20(1): 326-337, 2000

Hepatocyte growth factor/scatter factor augments motile activity of melanoma cells via down-regulation of E-cadherin expression. Journal of Dermatological Science 34(2): 133, April, 2004

Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma. Molecular Cancer Therapeutics 8(10): 2803-2810, 2010

N-cadherin promotes the differentiation of chick embryo epiblast cells into skeletal muscle. Molecular Biology of the Cell 7(SUPPL ): 40A, 1996

Hepatocyte growth factor/scatter factor promotes adhesion , migration and invasion of c-MET positive lymphoma cells. British Journal of Haematology 93(SUPPL 2): 290, 1996

Hepatocyte growth factor/scatter factor promotes proliferation, adhesion and survival of hemopoietic progenitor cells. British Journal of Haematology 93(SUPPL 2): 52-53, 1996

Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of p125-FAK and promotes migration and invasion of oral squamous carcinoma cells. Proceedings of the American Association for Cancer Research Annual Meeting 35(0): 54, 1994

Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. Journal of Biological Chemistry 269(50): 31807-31813, 1994

Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: a key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion. Clinical Cancer Research 7(10): 3289-3297, 2001

Effect of hepatocyte growth factor /scatter factor on the expression of E- and P-cadherin and related proteins in gastric carcinoma cell lines. Pathology Research & Practice 190(3): 234, 1994

Hepatocyte growth factor/scatter factor is produced by human bone marrow stromal cells and promotes proliferation, adhesion and survival of human hematopoietic progenitor cells. Experimental Hematology (Charlottesville) 26(9): 885-894, 1998

Hepatocyte growth factor/scatter factor (HGF/SF) is produced by human bone marrow stromal cells and promotes proliferation, adhesion and survival of human hematopoietic progenitor cells (CD34+). Experimental Hematology 26(9): 885-894, 1998

Hepatocyte growth factor/scatter factor promotes retinal angiogenesis through increased urokinase expression. Investigative Ophthalmology & Visual Science 48(4): 1793-1800, 2007

Local injection of hepatocyte growth factor/scatter factor promotes hair follicle growth in vivo. van Neste, D, Randall, V A International Congress Series; Hair research for the next millenium 433-435, 1996