EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Hereditary deficiency of vitamin-K-dependent coagulation factors in Rambouillet sheep


Hereditary deficiency of vitamin-K-dependent coagulation factors in Rambouillet sheep



Blood Coagulation and Fibrinolysis: An International Journal in Haemostasis and Thrombosis 10(2): 75-80



ISSN/ISBN: 0957-5235

PMID: 10192655

DOI: 10.1097/00001721-199903000-00003

A flock of Rambouillet sheep experienced unexpected lamb mortality associated with excessive bleeding at the time of parturition. Most lambs died of blood loss through the umbilicus or into subcutaneous tissues. Subsequently, nine ewes which had previously delivered lambs that bled to death were bred to the suspected sire of the previous bleeding lambs. Fifteen lambs were born alive the following Spring, and three males and one female bled clinically. These lambs had markedly decreased factor IX (< 16%) and factor X (< 4%) activities, with variably decreased factor II (11-36%) and factor VII (20-37%) activities. Protein C chromogenic activity was also markedly decreased (< 1%) in these lambs. The results from crossed immunoelectrophoresis and 'protein-induced-in-vitamin-K-absence' determination of the plasma of affected lambs, with antiserum directed against coagulation factor X, protein C or proteins S, suggested that these proteins were not carboxylated normally. Examination of liver from one lamb in the first batch and the four subsequent lambs did not reveal a known vitamin K antagonist. The breeding data suggested that the coagulopathy in these sheep was inherited as an autosomal recessive trait. The genetic or molecular defect that exists in these lambs is unknown, but possibilities include abnormal gamma-glutamyl carboxylase activity or abnormal metabolism of vitamin K.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010745375

Download citation: RISBibTeXText

Related references

Hereditary Deficiency of Vitamin K-dependent Coagulation Factors. Thrombosis and Haemostasis 84(12): 935-936, 2000

Hereditary deficiency of vitamin K-dependent coagulation factors. Thrombosis and Haemostasis 84(6): 935-936, 2000

Hereditary deficiency of vitamin K-dependent coagulation factors with skeletal abnormalities. American Journal of Medical Genetics 65(3): 241-243, 1996

Congenital defective carboxylation of vitamin K dependent coagulation factors in rambouillet lambs. Blood 90(10 Suppl. 1 Part 1): 467A, 1997

Congenital deficiency of all vitamin K-dependent blood coagulation factors due to a defective vitamin K-dependent carboxylase in Devon Rex cats. Thrombosis and Haemostasis 68(5): 521-525, 1992

The study of acquired vitamin K-dependent coagulation factors deficiency in 92 patients with coagulation disorders. Zhonghua Xue Ye Xue Za Zhi 33(3): 236-237, 2012

Congenital deficiency of vitamin K-dependent coagulation factors--a vitamin-K dependency state?. Thrombosis and Haemostasis 86(3): 932, 2001

Vitamin K-dependent coagulation factors deficiency. Seminars in Thrombosis and Hemostasis 35(4): 439-446, 2009

Deficiency of vitamin K-dependent coagulation factors. Clinical Research 41(4): 803A, 1993

The diagnostic value of protein induced by vitamin K absence or antagonist-II in non-infant patients with acquired deficiency of vitamin K-dependent coagulation factors. Zhonghua Nei Ke Za Zhi 53(2): 104-107, 2014

Congenital deficiency of vitamin K dependent coagulation factors in two families presents as a genetic defect of the vitamin K-epoxide-reductase-complex. Thrombosis and Haemostasis 84(6): 937-941, 2000

Congenital Deficiency of Vitamin K Dependent Coagulation Factors in Two Families Presents as a Genetic Defect of the Vitamin K-Epoxide-Reductase-Complex. Thrombosis and Haemostasis 84(12): 937-941, 2000

Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K-dependent coagulation factor deficiency. Blood 108(6): 1925-1931, 2006

Hereditary combined deficiency of the vitamin K-dependent clotting factors. Orphanet Journal of Rare Diseases 5: 21, 2010

Congenital deficiency of vitamin K-dependent coagulation factors and protein C. Thrombosis and Haemostasis 51(3): 343-346, 1984