+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells

Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells

Journal of Clinical Endocrinology and Metabolism 88(4): 1445-1452

ISSN/ISBN: 0021-972X

PMID: 12679420

DOI: 10.1210/jc.2002-021761

Patients with autoimmune polyendocrine syndrome type 1 often have autoantibodies against neurotransmitter synthesizing enzymes, including the pyridoxal phosphate-dependent enzymes glutamic acid decarboxylase and aromatic L-amino acid decarboxylase. Using a candidate approach, we have identified the histamine-synthesizing enzyme histidine decarboxylase, also pyridoxal phosphate dependent, as an autoantigen in this disorder. Anti-histidine decarboxylase antibodies reacting with in vitro translated antigen were found in 36/97 (37%) of autoimmune polyendocrine syndrome type 1 patients studied. The antibodies also reacted with the native enzyme in HMC-1 cell lysates and did not cross-react with the highly homologous aromatic L-amino acid decarboxylase. Anti-histidine decarboxylase antibodies were associated with a history of intestinal dysfunction (P = 0.017). Gastric and duodenal biopsies from a patient with anti-histidine decarboxylase antibodies were studied by immunohistochemistry. The oxyntic mucosa was found to lack the histamine producing enterochromaffin-like cells, suggestive of an autoimmune destruction. To our knowledge, this is the first report of autoantibodies against histidine decarboxylase and absence of gastric enterochromaffin-like cells.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 010755649

Download citation: RISBibTeXText

Related references

Aromatic- L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a b-cell autoantigen. Proceedings of the National Academy of Sciences of the United States of America 92: 26-9, 1995

Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen. Proceedings of the National Academy of Sciences of the United States of America 92(19): 8626-8629, 1995

The Catalytic Mechanism of the Pyridoxal-5'-phosphate-Dependent Enzyme, Histidine Decarboxylase: A Computational Study. Chemistry 23(38): 9162-9173, 2017

The C-terminus of rat L-histidine decarboxylase specifically inhibits enzymic activity and disrupts pyridoxal phosphate-dependent interactions with L-histidine substrate analogues. Biochemical Journal 381(Pt 3): 769-778, 2004

Pyridoxal phosphate-dependent histidine decarboxylase from Morganella AM-15. Methods in Enzymology 122: 139-143, 1986

Pyridoxal phosphate dependent bacterial histidine decarboxylase. Evangelopoulos, A E (Ed ) Progress in Clinical And Biological Research, Vol 144a Chemical And Biological Aspects Of Vitamin B6 Catalysis: Part A: Metabolism, Structure, And Function Of Phosphorylases, Decarboxylases, And Other Enzymes; 121st International Union Of Biochemistry Symposium, Athens, Greece, May 29-June 3, 1983 Xxiii+408p Alan R Liss, Inc : New York, N Y , Usa Illus P235-244, 1984

Inhibition of histidine decarboxylase and other pyridoxal phosphate dependent enzymes. Naunyn-Schmiedeberg's Archives of Pharmacology 279(Suppl): R-34, 1973

Pyridoxal 5'-phosphate-dependent histidine decarboxylase: mechanism of inactivation by α-fluoromethylhistidine. The Journal of Biological Chemistry 265(12): 6664-6668, 1990

Purification and properties of a pyridoxal 5'-phosphate-dependent histidine decarboxylase from Morganella morganii AM-15. Journal of Biological Chemistry 260(11): 6738-6746, 1985

Pyridoxal 5'-phosphate-dependent histidine decarboxylase. Mechanism of inactivation by alpha-fluoromethylhistidine. Journal of Biological Chemistry 265(12): 6664-6668, 1990

Isotope effect studies of the pyridoxal 5'-phosphate dependent histidine decarboxylase from Morganella morganii. Biochemistry 27(16): 5927-5933, 1988

Phosphopyridoxal complexes with histamine and histidine. (4) The kinetics of complex formation between histidine and pyridoxal 5' -phosphate in the presence of bacterial histidine decarboxylase. Agents and Actions 5(5): 471-475, 1975

In vitro studies of brain histidine decarboxylase activities dependent and independent of free pyridoxal phosphate. Neuroscience Letters Suppl (26): S487, 1986

New structural insights to help in the search for selective inhibitors of mammalian pyridoxal 5'-phosphate-dependent histidine decarboxylase. Inflammation Research 55(Suppl 1): S55-S56, 2006

Pyridoxal 5'-phosphate-dependent histidine decarboxylase. Inactivation by a-fluoromethylhistidine and comparative sequences at the inhibitor- and coenzyme-binding sites. The Journal of Biological Chemistry 261: 003-9, 1986