+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Histologic chorioamnionitis is associated with fetal growth restriction in term and preterm infants



Histologic chorioamnionitis is associated with fetal growth restriction in term and preterm infants



American Journal of Obstetrics and Gynecology 183(5): 1094-1099



Our aim was to evaluate associations between chorioamnionitis and fetal growth restriction in infants enrolled in the Collaborative Perinatal Project. A total of 2579 nonanomalous, singleton infants delivered at 28 to 44 weeks' gestation with chorioamnionitis were matched 1:3 for ethnicity, gestational age, parity, and maternal cigarette use (all of which were correlated with both chorioamnionitis and markers of fetal growth restriction) with 7732 control infants. Moderate or marked leukocytic infiltrates of the placenta defined chorioamnionitis. Birth weight, length, head circumference, weight/length ratio, ponderal index, and birth weight/head circumference ratio in the lowest 5th percentile were markers of fetal growth restriction. Placental weight and the birth weight/placental weight ratio were also evaluated. Compared with data on matched control infants, histologic chorioamnionitis was associated with all markers of fetal growth restriction and with low birth weight/placental weight ratios (odds ratios, 1.3-1.7). The strongest associations were found at 28 to 32 weeks' gestation (odds ratios, 2.2-11). Attributable risks for several markers of fetal growth restriction exceeded 50% in infants born at <33 weeks' gestation. Histologic chorioamnionitis is associated with multiple markers of fetal growth restriction, with stronger associations noted in prematurity.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010756034

Download citation: RISBibTeXText

PMID: 11084547

DOI: 10.1067/mob.2000.108866


Related references

Chorioamnionitis is associated with increased rates of fetal growth restriction in term and pre-term infants. American Journal of Obstetrics & Gynecology 182(1 Part 2): S98, 2000

Mild to Moderate, but Not Minimal or Severe, Acute Histologic Chorioamnionitis or Intra-Amniotic Inflammation Is Associated with a Decrease in Respiratory Distress Syndrome of Preterm Newborns without Fetal Growth Restriction. Neonatology 108(2): 115-123, 2015

Histologic chorioamnionitis, fetal involvement, and antenatal steroids: effects on neonatal outcome in preterm infants. American Journal of Obstetrics and Gynecology 201(6): 587.E1-8, 2009

Histologic chorioamnionitis in preterm infants: correlation with brain magnetic resonance imaging at term equivalent age. Bmc Pediatrics 18(1): 63, 2018

Contribution of Histologic Chorioamnionitis and Fetal Inflammatory Response Syndrome to Increased Risk of Brain Injury in Infants With Preterm Premature Rupture of Membranes. Pediatric Neurology 61: 94-98.E1, 2016

Placental Infection With Ureaplasma species Is Associated With Histologic Chorioamnionitis and Adverse Outcomes in Moderately Preterm and Late-Preterm Infants. Journal of Infectious Diseases 213(8): 1340-1347, 2016

Does the antenatal detection of fetal growth restriction (FGR) have a prognostic value for mortality and short-term morbidity for very preterm infants? Results from the MOSAIC cohort. Journal of Maternal-Fetal and Neonatal Medicine 29(4): 596-601, 2016

Cervical fetal fibronectin: An index of intra-amniotic inflammation, histologic chorioamnionitis and impending preterm delivery in patients with preterm labor and intact membranes. 2007

Reply-histologic chorioamnionitis and neonatal outcome in preterm infants. Pediatrics and Neonatology 55(2): 156, 2014

Histologic chorioamnionitis, neonatal brain injury and neurodevelopmental outcome in preterm infants. Pediatric Research 51(4 Part 2): 368A, 2002

Histologic chorioamnionitis is associated with reduced risk of late-onset sepsis in preterm infants. Pediatrics 129(1): E134-E141, 2012

Impact of histologic chorioamnionitis on pulmonary hypertension and respiratory outcomes in preterm infants. Pulmonary Circulation 8(2): 2045894018760166, 2018

Correlation between nucleated red blood cell counts and histologic chorioamnionitis in preterm infants. American Journal of Obstetrics & Gynecology 176(1 Part 2): S60, 1997

Persistent Pulmonary Hypertension and Histologic Chorioamnionitis in Preterm Infants: Controlled Study. Pediatric Cardiology 39(4): 705-708, 2018

Association of respiratory distress syndrome and perinatal hypoxia with histologic chorioamnionitis in preterm infants. Turkish Journal of Pediatrics 56(1): 56-61, 2015