+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells



Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells



Blood 100(12): 4139-4145



Little is known about the distribution in normal cells of CLIP-170, a linkage mediator between endocytic vesicles and microtubules, and restin, a splice variant encoded by the same gene and marker for Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin disease. Although only trace amounts of CLIP-170/restin are present in peripheral blood mononuclear cell subpopulations, monocyte-derived dendritic cells (DCs) and interleukin-4 (IL-4) + CD40L-activated B cells express high levels of CLIP-170/restin. CLIP-170/restin colocalizes preferentially with membranes of intermediate macropinocytic vesicles, suggesting a new function of CLIP-170/restin in the trafficking of macropinosomes to the cytoskeleton, which is a crucial step in antigen presentation. The strong expression of CLIP-170/restin in HRS cells, DCs, and activated B cells underscores their functional similarities supporting a function-based concept of HRS cells as professional antigen-presenting cells.

(PDF emailed within 0-6 h: $19.90)

Accession: 010757916

Download citation: RISBibTeXText

PMID: 12433698

DOI: 10.1182/blood.v100.12.4139


Related references

An immunohistochemical analysis of Reed-Sternberg-like cells in posttransplantation lymphoproliferative disorders: The possible pathogenetic relationship to Reed-Sternberg cells in Hodgkin's disease and Reed-Sternberg-like cells in non-Hodgkin's lymphomas and reactive conditions. Human Pathology 28(4): 493-498, 1997

Cytokine gene expression in Hodgkin and Reed-Sternberg cells of Hodgkins disease by single-cell global PCR IL-1 and TNF-alpha but not IL-2, IL-4 and IFN-gamma are produced by Hodgkin and Reed-Sternberg cells. Blood 86(10 SUPPL 1): 179A, 1995

Hodgkin and Reed-Stenberg-like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell-derived clones: Potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease. Blood 95(3): 1023-1031, Feb 1, 2000

Lymphocyte functional antigens stabilize agglutination between Reed-Sternberg cells and T cells, but are not responsible for homotypic binding of Hodgkin's Reed-Sternberg cells. American Journal of Pathology 137(3): 563-574, 1990

Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus. Cytogenetics and Cell Genetics 65(3): 172-176, 1994

Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?. American Journal of Pathology 150(2): 543-562, 1997

Localization of the gene (Rsim) coding for restin, a marker for Reed-Sternberg cells in Hodgkin’s disease, to human chromosome band 12q24.3 and Yac cloning of the locus. Cytogenetic and Genome Research 65(3): 172-176, 1994

Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease. Embo Journal 11(6): 2103-2113, 1992

CD30 is involved in inhibition of T-cell proliferation by Hodgkin's Reed-Sternberg cells. Cancer Research 64(6): 2148-2152, 2004

Hodgkin and Sternberg-Reed cells--cell origin, cell marker, cell function. Archiv für Geschwulstforschung 58(6): 419-430, 1988

Hodgkin and Reed-Sternberg cells express functional c-kit receptors and interact with primary fibroblasts from Hodgkin's disease-involved lymph nodes through soluble and membrane-bound stem cell factor. British Journal of Haematology 118(4): 1055-1064, 2002

Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease. Blood 84(7): 2305-2314, 1994

Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions. Blood 97(3): 818-821, 2001

Varied B-cell immunophenotypes of Hodgkin/Reed-Sternberg cells in classic Hodgkin's disease. Histopathology 36(4): 353-361, 2000

Clonality and germinal centre B-cell derivation of Hodgkin/Reed-Sternberg cells in Hodgkin's disease. Annals of Oncology 9(Suppl 5): S17-S20, 1998