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HpkA, a histidine protein kinase homolog, is required for fruiting body development in Myxococcus xanthus

HpkA, a histidine protein kinase homolog, is required for fruiting body development in Myxococcus xanthus

Journal of Microbiology and Biotechnology 13(3): 400-405

ISSN/ISBN: 1017-7825

A gene (hpkA), encoding a histidine protein kinase homolog, has been identified in the upstream region of the espAB operon in Myxococcus xanthus. It encodes a 333 amino acid (35,952 Da) protein with a histidine protein kinase domain in the region from amino acid 90 to 317. Null mutations in the hpkA gene caused formation of loose irregular fruiting bodies, while wild-type strains developed tight hemispherical fruiting bodies under developmental conditions. Sporulation of the hpkA mutant was delayed by at least 12 h compared to that of the wild-type. It appeared that the hpkA mutation increased the expression of the espAB operon by more than 2-fold compared with the wild-type under developmental conditions. Expression of the hpkA gene was low under vegetative conditions, but was highly induced under developmental conditions.

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Accession: 010763669

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