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Human coronavirus 229E: Receptor binding domain and neutralization by soluble receptor at 37degreeC



Human coronavirus 229E: Receptor binding domain and neutralization by soluble receptor at 37degreeC



Journal of Virology 77(7): 4435-4438



Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37degreeC, but not 4degreeC. Binding of hAPN may therefore trigger conformational changes in the viral spike protein at 37degreeC that facilitate virus entry.

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Accession: 010765317

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PMID: 12634402


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