+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Human monoclonal anti-phospholipid antibodies selectively bind to membrane phospholipid and beta2-glycoprotein I (beta2-GPI) on apoptotic cells

Human monoclonal anti-phospholipid antibodies selectively bind to membrane phospholipid and beta2-glycoprotein I (beta2-GPI) on apoptotic cells

Clinical and Experimental Immunology 119(3): 533-543

The ability of an anti-phospholipid (LJ1) and an anti-beta2-GPI (RSP-57) human MoAb to bind to apoptotic but not viable cells was demonstrated in this study. Both MoAbs were derived from patients with systemic lupus erythematosus and anti-phospholipid antibody syndrome. The parallel analysis of the specificity and affinity of four anti-phospholipid human MoAbs suggests that the binding of LJ1 MoAb to apoptotic cells is a specific property of this MoAb.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 010767245

Download citation: RISBibTeXText

PMID: 10691928

Related references

Human monoclonal antiphospholipid antibodies bind to membrane phospholipid and a cryptic epitope of beta2 glycoprotein 1 on apoptotic cells. Arthritis & Rheumatism 41(9 Suppl. ): S166, 1998

Anti-phospholipid and anti-beta2-glycoprotein I human monoclonal antibodies bind a monoblastoid cell line undergoing apoptosis. Lupus 7(Suppl. 2): S175, 1998

The prevalence of a non-phospholipid-binding form of beta2-glycoprotein I in human plasma--consequences for the development of anti-beta2-glycoprotein I antibodies. Thrombosis and Haemostasis 80(5): 791-797, 1998

Dimerization of beta2-glycoprotein I induces a significant increase in the affinity of anti-beta2-glycoprotein I antibodies from human anti-phospholipid syndrome sera. Arthritis & Rheumatism 41(9 Suppl. ): S171, 1998

Ser316Ser beta2-glycoprotein-I variant with reduced binding to phospholipid associated with anti-beta2-glycoprotein I antibodies in a patient with pregnancy complications. Lupus 11(9): 609, 2002

Interaction of giant phospholipid vesicles containing cardiolipin and cholesterol with beta2-glycoprotein-I and anti-beta2-glycoprotein-I antibodies. Autoimmunity Reviews 6(1): 10-15, 2006

Budding, vesiculation and permeabilization of phospholipid membranes-evidence for a feasible physiologic role of beta2-glycoprotein I and pathogenic actions of anti-beta2-glycoprotein I antibodies. Biochimica et Biophysica Acta 1740(1): 38-44, 2005

The anti-beta2-glycoprotein I activity in human anti-phospholipid syndrome sera is due to monoreactive low-affinity autoantibodies directed to epitopes located on native beta2-glycoprotein I and preserved during species' evolution. Journal of Immunology 157(12): 5732-5738, 1996

Induction of anti-phospholipid antibodies by phospholipid-bound beta2-glycoprotein I. Arthritis & Rheumatism 42(9 Suppl. ): S113, 1999

In vivo pathogenic properties of monoclonal antibodies against the phospholipid binding site of human beta2 glycoprotein 1. Blood 90(10 Suppl. 1 Part 1): 289A, 1997

Anti-phospholipid antibodies in HIV infection and SLE with or without anti-phospholipid syndrome: comparisons of phospholipid specificity, avidity and reactivity with beta2-GPI. Journal of Autoimmunity 13(3): 347-355, 1999

Induction of anti-phospholipid autoantibodies by beta2-glycoprotein I bound to apoptotic thymocytes. Journal of Autoimmunity 11(5): 413-424, 1998

Beta2-glycoprotein I (beta2-GPI) mRNA is expressed by several cell types involved in anti-phospholipid syndrome-related tissue damage. Clinical and Experimental Immunology 115(1): 214-219, 1999

Monoclonal antibodies influencing phospholipid molecules binding to beta 2 glycoprotein I (beta2-GPI). Dokladi na B"lgarskata Akademiya na Naukite 55(6): 87-92, 2002

Cellular autoimmune response against beta2-glycoprotein I in anti-phospholipid syndrome: II. Activation of T cells in patients with anti-phospholipid syndrome. Dokladi na B"lgarskata Akademiya na Naukite 56(3): 75-80, 2003