Section 11
Chapter 10,776

Hypoxia may increase rat insulin mRNA levels by promoting binding of the polypyrimidine tract-binding protein (PTB) to the pyrimidine-rich insulin mRNA 3'-untranslated region

Tillmar, L.; Welsh, N.

Molecular Medicine 8(5): 263-272


ISSN/ISBN: 1076-1551
PMID: 12359957
DOI: 10.1007/bf03402152
Accession: 010775908

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Background: Recent reports identify the 3'-UTR of insulin mRNA as crucial for control of insulin messenger stability. This region contains a pyrimidine-rich sequence, which is similar to the hypoxia-responsive mRNA-stabilizing element of tyrosine hydroxylase. This study aimed to determine whether hypoxia affects insulin mRNA levels. Materials and Methods: Rat islets were incubated at normoxic or hypoxic conditions and with or without hydrogen peroxide and a nitric oxide donor.

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