Section 11
Chapter 10,777

Hypoxia-induced modification of poly (ADP-ribose) polymerase and dna polymerase beta activity in cerebral cortical nuclei of newborn piglets: role of nitric oxide

Mishra, O.P.; Akhter, W.; Ashraf, Q.M.; Delivoria-Papadopoulos, M.

Neuroscience 119(4): 1023-1032


ISSN/ISBN: 0306-4522
PMID: 12831861
Accession: 010776028

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Previous studies have shown that poly (ADP-ribose) polymerase (PARP) and DNA polymerase beta, nuclear enzymes, are associated with cell replication and DNA repair. The present study tests the hypothesis that hypoxia results in increased PARP and DNA polymerase activity in cerebral cortical neuronal nuclei to repair the hypoxia-induced damage to genomic DNA.

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