Hypoxia-induced modification of poly (ADP-ribose) polymerase and dna polymerase beta activity in cerebral cortical nuclei of newborn piglets: role of nitric oxide
Mishra, O.P.; Akhter, W.; Ashraf, Q.M.; Delivoria-Papadopoulos, M.
Neuroscience 119(4): 1023-1032
2003
ISSN/ISBN: 0306-4522 PMID: 12831861 Accession: 010776028
Previous studies have shown that poly (ADP-ribose) polymerase (PARP) and DNA polymerase beta, nuclear enzymes, are associated with cell replication and DNA repair. The present study tests the hypothesis that hypoxia results in increased PARP and DNA polymerase activity in cerebral cortical neuronal nuclei to repair the hypoxia-induced damage to genomic DNA.
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Related References
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