IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma
Medoff, B.D.; Sauty, A.; Tager, A.M.; Maclean, J.A.; Smith, R.Neal.; Mathew, A.; Dufour, J.H.; Luster, A.D.
Journal of Immunology 168(10): 5278-5286
ISSN/ISBN: 0022-1767 PMID: 11994485 Accession: 010776811
Allergic asthma is an inflammatory disease of the airways characterized by eosinophilic inflammation and airway hyper-reactivity. Cytokines and chemokines specific for Th2-type inflammation predominate in asthma and in animal models of this disease. The role of Th1-type inflammatory mediators in asthma remains controversial. IFN-gamma-inducible protein 10 (IP-10; CXCL10) is an IFN-gamma-inducible chemokine that preferentially attracts activated Th1 lymphocytes.