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Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

Haze, K.; Okada, T.; Yoshida, H.; Yanagi, H.; Yura, T.; Negishi, M.; Mori, K.

Biochemical Journal 355(Pt 1): 19-28

2001


ISSN/ISBN: 0264-6021
PMID: 11256944
DOI: 10.1042/0264-6021:3550019
Accession: 010788573

Eukaryotic cells control the levels of molecular chaperones and folding enzymes in the endoplasmic reticulum (ER) by a transcriptional induction process termed the unfolded protein response (UPR). The mammalian UPR is mediated by the cis-acting ER stress response element consisting of 19 nt (CCAATN9CCACG), the CCACG part of which is considered to provide specificity.

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