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Impact of prenatal diagnosis and elective termination on the prevalence of selected birth defects in Hawaii



Impact of prenatal diagnosis and elective termination on the prevalence of selected birth defects in Hawaii



American Journal of Epidemiology 148(12): 1206-1211



A surveillance study was conducted to examine the effects of prenatal diagnosis and elective terminations on the prevalence of neural tube defects (NTDs), oral clefts, abdominal wall defects, and chromosomal anomalies in Hawaii. The analysis involved 10 years of data collected through the Hawaii Birth Defects Program during 1987-96; the data comprised all reported cases of anencephaly, spina bifida, encephalocele, cleft palate, cleft lip with or without cleft palate, omphalocele, gastroschisis, Down syndrome, trisomy 18, and trisomy 13. Findings showed that there were 211 infants with NTDs (87% anencephaly, 62% spina bifida, and 83% encephalocele), 376 infants with oral cleft (14% cleft lip with or without cleft palate), 117 with abdominal wall defects (60% omphalocele and 76% gastroschisis), and 449 chromosomal anomalies (43% Down's syndrome, 61% trisomy 18, and 40% trisomy 13). Prenatal diagnosis and elective pregnancy terminations have a significant impact on the birth prevalence rates of NTDs and chromosomal anomalies. These finding have important implications for other birth defects surveillance programs.

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Accession: 010802281

Download citation: RISBibTeXText

PMID: 9867267

DOI: 10.1093/oxfordjournals.aje.a009610


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