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In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

Neurobiology of Aging 20(3): 325-30; Discussion 339-42

The amyloid beta-peptide (Abeta)-associated free radical oxidative stress model for neuronal death in Alzheimer's disease (AD) brain predicts that neuronal protein oxidation is a consequence of Abeta-associated free radicals (8). In this study we have used both in vitro and in vivo models of beta-amyloid (Abeta) toxicity to detect free radical induced oxidative stress by the measure of protein carbonyl levels.

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Accession: 010812312

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PMID: 10588580

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