+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2



Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2



Acta Neuropathologica 103(2): 157-162



We report that overexpression of human (h) cyclooxygenase-2 h(COX-2) in the brain of a transgenic mouse line leads to selective induction of endogenous complement component C1qB expression in neurons. No detectable induction of the C3 and C4 complement components in the brain was found. Chronic treatment of mice with the selective COX-2 inhibitor nimesulide reduced the hCOX-2-mediated induction of hippocampal C1qB mRNA expression. The data suggest that neuronal COX-2 expression may influence inflammatory responses in the brain, in part through modulation of complement gene expression. Because there is extensive evidence that C1q and other complement components are involved in Alzheimer's disease (AD) neurodegeneration, this study advances our understanding of the apparent benefits of COX-2 inhibition in AD.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010833303

Download citation: RISBibTeXText

PMID: 11810182

DOI: 10.1007/s004010100447


Related references

Increased neuronal injury in transgenic mice with neuronal overexpression of human cyclooxygenase-2 is reversed by hypothermia and rofecoxib treatment. Current Neurovascular Research 4(4): 274-279, 2007

Increased Neuronal Injury in Transgenic Mice with Neuronal Overexpression of Human Cyclooxygenase-2 is reversed by Hypothermia and Rofecoxib Treatment. Current Neurovascular Research 4(4): 274-279, 2007

Transgenic mice with neuronal overexpression of human cyclooxygenase-2 A model of Alzheimers disease neurodegeneration. Society for Neuroscience Abstracts 24(1-2): 727, 1998

Overexpression of neuronal cyclooxygenase -2 promotes amyloid deposition in the brain of transgenic mice with Alzheimers disease type neuropathology. Society for Neuroscience Abstracts 27(2): 1728, 2001

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is potentiated in mice with neuronal overexpression of human cyclooxygenase-2. Society for Neuroscience Abstracts 25(1-2): 327, 1999

Morphological and architectural changes in brain vasculature of app23 transgenic mice with neuronal overexpression of mutant app. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 295 10, 2002

Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 292(1): R373-R381, 2006

Transgenic mice with neuronal overexpression of ABAD and mutant APP display impaired synaptic transmission and decreased brain ATP. Society for Neuroscience Abstracts 27(1): 925, 2001

Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice. Neuroscience 113(4): 797-808, 2002

The third complement component is associated with amyloid plaques in human APP695SWE transgenic mice. Society for Neuroscience Abstracts 24(1-2): 730, 1998

Overexpression of cyclooxygenase -2 in mammary glands of transgenic mice. Molecular Biology of the Cell 11(Supplement): 435a-436a, 2000

Overexpression of the human dopamine D3 receptor in the brain of transgenic mice. Society for Neuroscience Abstracts 19(1-3): 1689, 1993

Amelioration of hippocampal neuronal damage after global ischemia by neuronal overexpression of BCL-2 in transgenic mice. Stroke 29(12): 2616-2621, 1998

Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. Journal of Biological Chemistry 276(21): 18563-9, 2001

Expression of complement C1qB and C4 mRNAs during rat brain development. Brain Research. Developmental Brain Research 80(1-2): 163-174, 1994