+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Influence of insulin sensitivity and the TaqIB cholesteryl ester transfer protein gene polymorphism on plasma lecithin:cholesterol acyltransferase and lipid transfer protein activities and their response to hyperinsulinemia in non-diabetic men



Influence of insulin sensitivity and the TaqIB cholesteryl ester transfer protein gene polymorphism on plasma lecithin:cholesterol acyltransferase and lipid transfer protein activities and their response to hyperinsulinemia in non-diabetic men



Journal of Lipid Research 40(8): 1467-1474



Lecithin:cholesteryl acyl transferase (LCAT), cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), and lipoprotein lipases are involved in high density lipoprotein (HDL) metabolism. We evaluated the influence of insulin sensitivity and of the TaqIB CETP gene polymorphism (B1B2) on plasma LCAT, CETP, and PLTP activities (measured with exogenous substrates) and their responses to hyperinsulinemia. Thirty-two non-diabetic men without hyperlipidemia were divided in quartiles of high (Q(1)) to low (Q(4)) insulin sensitivity. Plasma total cholesterol, very low + low density lipoprotein cholesterol, triglycerides, and apolipoprotein (apo) B were higher in Q(4) compared to Q(1) (P < 0.05 for all), whereas HDL cholesterol and apoA-I were lowest in Q(4) (P < 0.05 for both). Plasma LCAT activity was higher in Q(4) than in Q(1) (P < 0. 05) and PLTP activity was higher in Q(4) than in Q(2) (P < 0.05). Insulin sensitivity did not influence plasma CETP activity. Postheparin plasma lipoprotein lipase activity was highest and hepatic lipase activity was lowest in Q(1). Insulin infusion decreased PLTP activity (P < 0.05), irrespective of the degree of insulin sensitivity. The CETP genotype exerted no consistent effects on baseline plasma lipoproteins and LCAT, CETP, and PLTP activities. The decrease in plasma PLTP activity after insulin was larger in B1B1 than in B2B2 homozygotes (P < 0.05). These data suggest that insulin sensitivity influences plasma LCAT, PLTP, lipoprotein lipase, and hepatic lipase activities in men. As PLTP, LCAT, and hepatic lipase may enhance reverse cholesterol transport, it is tempting to speculate that high levels of these factors in association with insulin resistance could be involved in an antiatherogenic mechanism. A possible relationship between the CETP genotype and PLTP lowering by insulin warrants further study.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 010840177

Download citation: RISBibTeXText

PMID: 10428983


Related references

Acute and chronic effects of a 24-hour intravenous triglyceride emulsion challenge on plasma lecithin: cholesterol acyltransferase, phospholipid transfer protein, and cholesteryl ester transfer protein activities. Journal of Lipid Research 40(8): 1459-1466, 1999

High-density lipoprotein cholesterol is related to the TaqIB cholesteryl ester transfer protein gene polymorphism and smoking, but not to moderate alcohol consumption in insulin-dependent diabetic men. Scandinavian Journal of Clinical and Laboratory Investigation 58(3): 251-258, 1998

Distribution and functions of lecithin cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins evidence for a functional unit containing these activities together with apolipoproteins a i and d that catalyzes the esterification and transfer of cell derived cholesterol. Journal of Biological Chemistry 264(12): 7066-7072, 1989

Plasma phospholipid transfer protein, cholesteryl ester transfer protein and lecithin:cholesterol acyltransferase in end-stage renal disease (ESRD). Nephrology, Dialysis, Transplantation 24(8): 2541-2546, 2009

The ability of plasma to stimulate fibroblast cholesterol efflux is associated with the-629C -> A cholesteryl ester transfer protein promoter polymorphism: Role of Lecithin : Cholesterol acyltransferase activity. Biochimica et Biophysica Acta 1781(1-2): 10-15, 2008

Association of TaqIB polymorphism in the cholesteryl ester transfer protein gene with plasma lipid levels in a healthy Spanish population. Atherosclerosis 152(2): 367-376, 2000

Localization of lecithin cholesterol acyltransferase and cholesteryl ester transfer protein activities in a i containing lipoproteins. American Heart Association Monograph (114): III-365, 1985

HDL cholesterol and TaqIB cholesteryl ester transfer protein gene polymorphism in renal transplant recipients. Nephron 84(4): 333-341, 2000

Hdl Cholesterol and TaqIb Cholesteryl Ester Transfer Protein Gene Polymorphism in Renal Transplant Recipients. Nephron 84(4): 333-341, 2000

Changes in lecithin: cholesterol acyltransferase, cholesteryl ester transfer protein and paraoxonase-1 activities in patients with colorectal cancer. Clinical Biochemistry 2018, 2018

Effect of the cholesteryl ester transfer protein taqib gene polymorphism on parameters of the insulin resistance syndrome. Diabetologia 44(Supplement 1): A 95, 2001

Increased lecithin Cholesterol acyltransferase and cholesteryl ester transfer protein activities, and abnormal lipoprotein profiles in proteinuric patients. European Journal of Clinical Investigation 23(SUPPL 1): A45, 1993

Role of elevated lecithin: cholesterol acyltransferase and cholesteryl ester transfer protein activities in abnormal lipoproteins from proteinuric patients. Kidney International 44(1): 91-97, 1993

Interaction of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in the transport of cholesteryl ester into sphingomyelin liposomes. Biochemistry 19(16): 3673-3677, 1980

TaqIB polymorphism in the cholesteryl ester transfer protein (CETP) gene influences lipid responses to the consumption of kiwifruit in hypercholesterolaemic men. British Journal of Nutrition 111(6): 1077-1084, 2014