EurekaMag
+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Influence of respiratory syncytial virus infection on cytokine and inflammatory responses in allergic mice


Influence of respiratory syncytial virus infection on cytokine and inflammatory responses in allergic mice



Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 32(3): 463-471



ISSN/ISBN: 0954-7894

PMID: 11940079

DOI: 10.1046/j.1365-2222.2002.01317.x

Background Th2 lymphocyte responses are associated with inflammation and disease during allergic responses. Exposure to particular environmental factors during the expression of allergy could result in more pronounced Th2-like immune responses and more severe disease. One factor might be a respiratory virus infection. Objective The aim of our study was to investigate the influence of respiratory syncytial virus (RSV) infection on the expression of ovalbumin (OVA)-induced allergy in BALB/c mice. Methods We determined OVA-specific IgE in serum, cytokine profiles and histopathological lesions in lungs of OVA-allergic mice after RSV infection. Results OVA sensitization and challenge induced OVA-specific IgE in serum, Th2 cytokine mRNA expression, and mononuclear and eosinophilic inflammation in the lungs. RSV inoculation during the challenge period enhanced OVA-induced IL-4 and IL-5 mRNA expression in lung tissue. RSV further enhanced the OVA-induced hypertrophy of mucous cells and eosinophilic infiltration in lung tissue. Surprisingly, RSV infection decreased Th2 cytokine secretion and eosinophilic influx in bronchoalveolar lavage of OVA-allergic mice. Because inactivated RSV did not influence these responses, replication of RSV appeared essential for the modification of OVA-induced Th2 cytokine expression. RSV did not change OVA-specific IgE levels in serum. Furthermore, the RSV-induced IL-12 mRNA expression in lung tissue of OVA-allergic mice was diminished, but IFN-gamma mRNA expression was not affected. Conclusion RSV infection enhanced particular OVA-induced Th2 cytokine mRNA responses and pulmonary lesions in allergic mice and thus aggravated allergic respiratory disease.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 010842309

Download citation: RISBibTeXText

Related references

Chemokines, cytokines, and inflammatory cells in respiratory syncytial virus infection: Similarities to allergic responses. Pediatric Asthma Allergy and Immunology 14(2): 93-100, 2000

Respiratory synctial virus infection in BALB/c mice previously immunized with formalin-inactivated virus induces enhanced pulmonary inflammatory response with a predominant Th2-like cytokine pattern. Journal of Virology 70(5): 2852-2860, 1996

Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus. Journal of General Virology 91(Part 5): 1302-1310, 2010

Cytokine responses in cord blood predict the severity of later respiratory syncytial virus infection. Journal of Allergy and Clinical Immunology 124(1): 52-58.E1-2, 2009

Cytokine responses in cord blood predict the severity of later respiratory syncytial virus infection. Journal of Allergy and Clinical Immunology 124(1): 52-58, 2009

Association of cytokine responses with disease severity in infants with respiratory syncytial virus infection. Acta Paediatrica 91(9): 914-922, 2002

Virus-specific memory and effector T lymphocytes exhibit different cytokine responses to antigens during experimental murine respiratory syncytial virus infection. Journal of Virology 71(1): 678-685, 1997

Effect of respiratory syncytial virus infection during early infancy on the ontogeny of cytokine immune responses. Allergy and Asthma Proceedings 23(6): 399-405, 2002

Respiratory syncytial virus predisposes mice to augmented allergic airway responses via IL-13-mediated mechanisms. Journal of Immunology 167(2): 1060-1065, 2001

Human infant respiratory syncytial virus (RSV)-specific type 1 and 2 cytokine responses ex vivo during primary RSV infection. Journal of Infectious Diseases 195(12): 1779-1788, 2007

IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection. Journal of Immunology 173(6): 4040-4049, 2004

Inflammatory responses to respiratory syncytial virus (RSV) infection and the development of immunomodulatory pharmacotherapeutics. Current Medicinal Chemistry 19(10): 1424-1431, 2012

Age-related differences in pulmonary cytokine response to respiratory syncytial virus infection: modulation by anti-inflammatory and antiviral treatment. Journal of Infectious Diseases 195(4): 511-518, 2007

Respiratory syncytial virus predisposes mice to augmented allergic airway responses via IL-13-mediated mechanisms (vol 167, pg 1060, 2001). Journal of Immunology 175(12): 8442, 2005

Respiratory syncytial virus infection does not increase allergen-induced Type 2 cytokine production, yet increases airway hyperresponsiveness in mice. Journal of Medical Virology 63(2): 178-188, 2001