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Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells

Wu, H.; MacFarlane, W.M.; Tadayyon, M.; Arch, J.R.; James, R.F.; Docherty, K.

Biochemical Journal 344 Pt 3: 813-818

1999

ISSN/ISBN: 0264-6021
PMID: 10585868
Accession: 010857497
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Pancreatic-duodenal homoeobox factor-1 (PDX1) is a homoeo-domain transcription factor that plays an important role in linking glucose metabolism in pancreatic beta cells to the regulation of insulin gene transcription. Our previous results indicated that glucose activates PDX1 DNA-binding activity and insulin promoter activity via a stress-activated signalling pathway involving phosphatidylinositol 3-kinase (PtdIns 3-kinase) and stress-activated protein kinase 2 (SAPK2/p38).

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Related References

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