Section 11
Chapter 10,858

Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells

Wu, H.; MacFarlane, W.M.; Tadayyon, M.; Arch, J.R.; James, R.F.; Docherty, K.

Biochemical Journal 344 Pt 3: 813-818


ISSN/ISBN: 0264-6021
PMID: 10585868
Accession: 010857497

Download citation:  

Pancreatic-duodenal homoeobox factor-1 (PDX1) is a homoeo-domain transcription factor that plays an important role in linking glucose metabolism in pancreatic beta cells to the regulation of insulin gene transcription. Our previous results indicated that glucose activates PDX1 DNA-binding activity and insulin promoter activity via a stress-activated signalling pathway involving phosphatidylinositol 3-kinase (PtdIns 3-kinase) and stress-activated protein kinase 2 (SAPK2/p38).

PDF emailed within 1 workday: $29.90