+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells

Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells

FEBS Letters 484(3): 271-274, 10 November

Expression of wild type HFE reduces the ferritin levels of cells in culture. In this report we demonstrate that the predominant hereditary hemochromatosis mutation, C282Y(2) HFE, does not reduce ferritin expression. However, the second mutation, H63D HFE, reduces ferritin expression to a level indistinguishable from cells expressing wild type HFE. Further, two HFE cytoplasmic domain mutations engineered to disrupt potential signal transduction, S335M and Y342C, were functionally indistinguishable from wild type HFE in this assay, as was soluble HFE. These results implicate a role for the interaction of HFE with the transferrin receptor in lowering cellular ferritin levels.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 010864495

Download citation: RISBibTeXText

PMID: 11078891

DOI: 10.1016/s0014-5793(00)02173-6

Related references

Transferrin receptor levels and polymorphism of its gene in age-related macular degeneration. Acta Biochimica Polonica 62(2): 177-184, 2015

Overexpression of the Lotus corniculatus Soloist Gene LcAP2/ERF107 Enhances Tolerance to Salt Stress. Protein and Peptide Letters 23(5): 442-449, 2016

HFE genotype influences erythropoiesis support requirement in hemodialysis patients: A prospective study. American Journal of Nephrology 28(2): 311-316, 2008

Transferrin receptor expression in testis cancer. Journal of the National Cancer Institute 86(8): 636-637, 1994

Entry of ingested plant viruses into the hemocoel of the plant virus vector, Diabrotica undecimpunctata howardii. Phytopathology 82(10): 1148, 1992

Soluble transferrin receptor and immature reticulocytes are not useful for distinguishing iron-deficiency anemia from heterozygous beta-thalassemia. Sao Paulo Medical Journal 121(2): 90-91, 2003

Structure-based mutagenesis of Penicillium griseofulvum xylanase using computational design. Proteins 72(4): 1298-1307, 2008

Effects of different toxic compounds (Pb, Cu, formol, NH4) on the carp: histologic changes in excretory and hematopoietic organs. European Journal of Toxicology and Environmental Hygiene. Journal Europeen de Toxicologie 8(6): 361-369, 1975

Intracellular recordings in the chloride cell-rich opercular epithelium of Fundulus heteroclitus. Bulletin of the Mount Desert Island Biological Laboratory. 1984 ; 24: 86-88, 1985

Transferrin receptor antibodies. Official Gazette of the United States Patent and Trademark Office Patents 1229(4), 1999

The role of hepatic stellate cells in the regulation of T-cell function and the promotion of hepatocellular carcinoma. International Journal of Oncology 41(2): 457-464, 2012

Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation. Nucleic Acids Research 29(9): 1989-1993, 2001

Hijacking the host ubiquitin pathway: structural strategies of bacterial E3 ubiquitin ligases. Current Opinion in Microbiology 13(1): 41-46, 2010